The Pediatric Rheumatology Tissue Repository (PRTR), a funded component of a PSO rheumatic disease core center, assists local and national investigators in specimen collection, processing, storage and distribution of biospecimens for rheumatic diseases-related studies. The principal functions of this core are: ? To collect, process and maintain biological specimens from patients with pediatric rheumatological and related musculoskeletal conditions as well as from relevant control populations for research purposes. Samples collected include blood, urine, synovial fluid, synovial tissue, hair and saliva. Products derived from these collections are suitable for genetic, genomic, proteomic, immunologic function and biomarker studies. ? To optimize the availability and potential for use of sample collections. Collection, processing and storage practices are optimized to meet current and future study needs and when possible standardized to be consistent with other national and international efforts. ? To provide high quality samples in an appropriate format for investigators conducting IRB-approved basic and translational studies in pediatric rheumatologic disease. Informatics solutions for sample storage documentation will allow accurate and appropriate use. Current systems have been optimized to allow information relative to consent, source of collection (study, extemal site, type of sample, etc), and specifics of handling/processing as well as prior use to be considered when accessing samples.

Public Health Relevance

Established practices of the PRTR for sample collection, processing shipping and training of clinical site personnel ensure that the scope of specimens needed for translational research projects are available. Thus, this unique resource is important to enabling definitive genomic and biological studies necessary to understand and define childhood rheumatic diseases.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZAR1-MLB)
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Cincinnati Children's Hospital Medical Center
United States
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Raghu, Harini; Jone, Alice; Cruz, Carolina et al. (2014) Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice. Arthritis Rheumatol 66:1504-16
Boespflug, Nicholas D; Kumar, Sachin; McAlees, Jaclyn W et al. (2014) ATF3 is a novel regulator of mouse neutrophil migration. Blood 123:2084-93
Moreno-Fernandez, Maria E; Joedicke, Jara J; Chougnet, Claire A (2014) Regulatory T Cells Diminish HIV Infection in Dendritic Cells - Conventional CD4(+) T Cell Clusters. Front Immunol 5:199
Donnelly, Jessica M; Engevik, Amy; Feng, Rui et al. (2014) Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach. Am J Physiol Gastrointest Liver Physiol 306:G1075-88
Cole, Heather A; Ohba, Tetsuro; Nyman, Jeffry S et al. (2014) Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice. Arthritis Rheumatol 66:2222-33
Huang, Wenting; Kachapati, Kritika; Adams, David et al. (2014) Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. J Autoimmun 50:123-34
Patel, Zubin H; Kottyan, Leah C; Lazaro, Sara et al. (2014) The struggle to find reliable results in exome sequencing data: filtering out Mendelian errors. Front Genet 5:16
Ardoin, Stacy P; Schanberg, Laura Eve; Sandborg, Christy I et al. (2014) Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein. Ann Rheum Dis 73:557-66
Suzuki, Takuji; Mayhew, Christopher; Sallese, Anthony et al. (2014) Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis. Am J Respir Crit Care Med 189:183-93
Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda et al. (2014) Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell. Dig Dis Sci 59:569-82

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