The proposed UCSF Core Center for Musculoskeletal Biology in Medicine (CCMBM) will be an interdisciplinary consortium of thirty-nine basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in osteoporosis and osteoarthritis. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between scientists who study disease biology, researchers who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology Core;2) Musculoskeletal and Quantitative Imaging Core;and 3) Epidemiology and Biostatistics Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program;the curriculum includes a monthly seminar featuring local and visiting scientists, an annual full-day retreat with the External Advisory board, and a quarterly half-day symposium with a rotating topic relevant to osteoporosis and osteoarthritis. Another vital component of the Center is its Pilot/Feasibility Program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology Grant Program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the proposed CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.

Public Health Relevance

A goal of the proposed CCMBM is to facilitate translating laboratory advances to the diagnosis and treatment of human musculoskeletal disease. It is organized in a manner to reflect the spirit of the broad, interdisciplinary mandate of NIAMS: to develop cross-cutting research that integrates many disciplines and involves the interplay and collaboration of a diverse array of specialists from both basic and clinical areas.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
1P30AR066262-01
Application #
8693342
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Tyree, Bernadette
Project Start
2014-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Orthopedics
Type
Schools of Medicine
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Joo, Adriane; Long, Roger; Cheng, Zhiqiang et al. (2016) Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone 88:170-9
Zhang, M; Wang, H; Zhang, J et al. (2016) Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage 24:921-31
Kim, Wonnam; Takyar, Farzin M; Swan, Karena et al. (2016) Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res 76:5348-60
Almubarak, Sarah; Nethercott, Hubert; Freeberg, Marie et al. (2016) Tissue engineering strategies for promoting vascularized bone regeneration. Bone 83:197-209
Jáuregui, Emmanuel J; Akil, Omar; Acevedo, Claire et al. (2016) Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone 89:7-15
Zhang, Alan L; Sing, David C; Dang, Debbie Y et al. (2016) Overlapping Surgery in the Ambulatory Orthopaedic Setting. J Bone Joint Surg Am 98:1859-1867
Santa Maria, Christian; Cheng, Zhiqiang; Li, Alfred et al. (2016) Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol 49:11-23
Degmetich, Sean; Bailey, Jeannie F; Liebenberg, Ellen et al. (2016) Neural innervation patterns in the sacral vertebral body. Eur Spine J 25:1932-8
Yang, T; Zhang, J; Cao, Y et al. (2015) Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res 94:803-12
Wang, Tao; Wang, Yongmei; Menendez, Alicia et al. (2015) Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res 30:1572-84

Showing the most recent 10 out of 14 publications