05 CANCER CHEMOPREVENTION (CCP) PROGRAM ABSTRACT The UAB Cancer Center Chemoprevention Program was established to identify novel chemopreventive agents capable of preventing cancer, to determine the ability of naturally occurring and synthetic chemicals to prevent or delay carcinogenesis, to determine their mechanisms of action and identify biomarkers, and to perform early phase chemoprevention trials evaluating novel chemopreventive agents. The focus of the Program is directed toward synthetic retinoids, non-steroidal anti-inflammatory drugs, and phytochemicals. However, the scope of the program and depth of expertise have been expanded by strategic recruitment and a mentoring program. Furthermore, transdisciplinary research is nurtured through focused working groups. This program is co- directed by Dr. Craig A. Elmets (Professor and Chair, Department of Dermatology and Director of the UAB Skin Diseases Research Center) and Dr. Clinton J. Grubbs (Professor, Department of Surgery and Director of the Chemoprevention Center). Currently, the program is comprised of 18 members from 10 departments and 5 schools. This program has $4,187,741 in annual direct cost funding, of which 76% is derived from the NCI. In addition to the traditional utilization of inter-programmatic teams and intra-programmatic collaborations, the capabilities of the program are greatly expanded by established extramural agreements: (1) Dr. Grubbs directs Task Order from the NCI PREVENT program which awards contracts to investigators both at UAB and other institutions, and (2) Dr. Elmets participates in an NCI-funded consortium of early phase human chemoprevention trials led by the University of Wisconsin. Over the past four years, the program has produced 206 publications, of which 35% % were intra-programmatic, 28%% were inter-programmatic, and 34% were inter-institutional. A vibrant communications component that includes a seminar series with lecturers from inside and outside the University supports collaborative research among program investigators. Major completed studies at UAB have moved chemopreventive agents from various classes (including rexinoids, cyclooxygenase inhibitors, and dietary polyphenols) to clinical trials during the last few years.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-46
Application #
9467459
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
46
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Buford, Thomas W; Carter, Christy S; VanDerPol, William J et al. (2018) Composition and richness of the serum microbiome differ by age and link to systemic inflammation. Geroscience 40:257-268
Kim, Harrison (2018) Variability in Quantitative DCE-MRI: Sources and Solutions. J Nat Sci 4:
Frugé, Andrew D; Van der Pol, William; Rogers, Laura Q et al. (2018) Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. J Acad Nutr Diet :
Pruitt, Hawley C; Metge, Brandon J; Weeks, Shannon E et al. (2018) Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors. Oncogene 37:1610-1623
Boitano, Teresa K L; Smith, Haller J; Rushton, Tullia et al. (2018) Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy. Gynecol Oncol 151:282-286
Jo, SeongHo; Chen, Junqin; Xu, Guanlan et al. (2018) miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function. Diabetes 67:256-264
Frugé, Andrew D; Ptacek, Travis; Tsuruta, Yuko et al. (2018) Dietary Changes Impact the Gut Microbe Composition in Overweight and Obese Men with Prostate Cancer Undergoing Radical Prostatectomy. J Acad Nutr Diet 118:714-723.e1
Crenshaw, Brennetta J; Gu, Linlin; Sims, Brian et al. (2018) Exosome Biogenesis and Biological Function in Response to Viral Infections. Open Virol J 12:134-148
Si, Ying; Cui, Xianqin; Crossman, David K et al. (2018) Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis. Neurobiol Dis 114:85-94
Sahay, Bikash; Bashant, Kathleen; Nelson, Nicole L J et al. (2018) Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun 86:

Showing the most recent 10 out of 747 publications