The Database Shared Resource (DBSR) is a new core within the Herbert Irving Comprehensive Cancer Center (HICCC), whose central function is to provide oversight and infrastructure for the development and maintenance of cancer-related clinical databases and link them to existing biobanks. Our overall objective is to stimulate multi-disciplinary clinical and translational research utilizing these databases and biobanks. Services provided include: Coordinating clinical database-related services with other shared resources Providing IT support for data storage, clinical data extraction, and quality measures Providing support and resources for questionnaire development for biobanks Disseminating information about the clinical databases and biobanks to the research community Reviewing requests to access the clinical databases and biobanks and tracking utilization There are currently sixteen cancer-related clinical databases and biobanks at Columbia University Medical Center (CUMC). Our goal is to standardize and streamline the management of these clinical databases and biobanks, ensure that they meet IRB, HIPAA, and CUMC IT Security requirements, and develop them into a valuable resource for the HICCC research community. This entails the coordination of efforts with other shared resources to facilitate recruitment and consenting of database participants, administration of epidemiologic questionnaires, collection of biospecimens, and extraction of clinical data from the cancer registry and electronic health record (EHR). Our future plans include integrating these cancer-related clinical database and biobanking efforts with the Personalized Medicine Research Initiative at CUMC and to develop more efficient ways of extracting clinical data from the EHR, including the use of patient portals. Our goal is to merge all of the disease-specific databases into one HICCC clinical database, which will enroll all newly diagnosed cancer patients and healthy at-risk individuals seen at our Cancer Center and link their epidemiologic questionnaire data and clinical information with tumor tissue, blood, DNA, and other biospecimens. The proposed total operating budget for the DBSR is $153,887, ofwhich we are requesting $35,223 from the CCSG.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013696-40
Application #
8753134
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-07-04
Project End
2019-06-30
Budget Start
2014-07-17
Budget End
2015-06-30
Support Year
40
Fiscal Year
2014
Total Cost
$50,233
Indirect Cost
$18,837
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Bassuk, Alexander G; Sujirakul, Tharikarn; Tsang, Stephen H et al. (2014) A novel RPGR mutation masquerading as Stargardt disease. Br J Ophthalmol 98:709-11
Li, Yao; Wu, Wen-Hsuan; Hsu, Chun-Wei et al. (2014) Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Mol Ther 22:1688-97
Wert, Katherine J; Sancho-Pelluz, Javier; Tsang, Stephen H (2014) Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet 23:514-23
Shen, Sherry; Sujirakul, Tharikarn; Tsang, Stephen H (2014) Next-generation sequencing revealed a novel mutation in the gene encoding the beta subunit of rod phosphodiesterase. Ophthalmic Genet 35:142-50
Palomero, Teresa; Couronné, Lucile; Khiabanian, Hossein et al. (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 46:166-70
Higuchi-Sanabria, Ryo; Pernice, Wolfgang M A; Vevea, Jason D et al. (2014) Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae. FEMS Yeast Res 14:1133-46
Lam, A T; Curschellas, C; Krovvidi, D et al. (2014) Controlling self-assembly of microtubule spools via kinesin motor density. Soft Matter 10:8731-6
Olszak, Torsten; Neves, Joana F; Dowds, C Marie et al. (2014) Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509:497-502
Murtomaki, Aino; Uh, Minji K; Kitajewski, Chris et al. (2014) Notch signaling functions in lymphatic valve formation. Development 141:2446-51
Nong, Eva; Lee, Winston; Merriam, Joanna E et al. (2014) Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene. Doc Ophthalmol 128:59-67

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