Abstract

Animal models created by transgenic and gene knockout technology are invaluable in evaluating gene function in vivo and in determining how certain genes regulate cell growth and differentiation and how alterations in these genes contribute to cancer. Mice are genetically modified in this facility either by pronucleus injection of DNA into fertilized eggs, by injection of retroviruses into the perivitteline space of fertilized eggs, or by injection of mutated embryonic stem cells (ES-cells) into blastocysts. The objective of this shared resource is to provide genetically modified mice to principal Investigators within the Cancer Center in the most time- and costeffective way. In addition, the availability of these mouse strains greatly stimulates interactions among investigators at St Jude.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA021765-34
Application #
8378656
Study Section
Special Emphasis Panel (ZCA1-RTRB-Z)
Project Start
Project End
2014-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
34
Fiscal Year
2012
Total Cost
$253,079
Indirect Cost
$102,424

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Zheng, Daniel J; Krull, Kevin R; Chen, Yan et al. (2018) Long-term psychological and educational outcomes for survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study. Cancer 124:3220-3230
Fatima, Soghra; Zhou, Sheng; Sorrentino, Brian P (2018) Marking of definitive HSC precursors in E7.5-E8.5 embryos using an Abcg2-CreER lineage-tracing mouse model. Exp Hematol 65:29-33
Chen, Wenan; Li, Yan; Easton, John et al. (2018) UMI-count modeling and differential expression analysis for single-cell RNA sequencing. Genome Biol 19:70
Snaman, J M; Talleur, A C; Lu, J et al. (2018) Treatment intensity and symptom burden in hospitalized adolescent and young adult hematopoietic cell transplant recipients at the end of life. Bone Marrow Transplant 53:84-90
Robinson, Giles W; Rudneva, Vasilisa A; Buchhalter, Ivo et al. (2018) Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial. Lancet Oncol 19:768-784
Creutzig, Ursula; Kutny, Matthew A; Barr, Ronald et al. (2018) Acute myelogenous leukemia in adolescents and young adults. Pediatr Blood Cancer 65:e27089
Gilleland Marchak, Jordan; Seidel, Kristy D; Mertens, Ann C et al. (2018) Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 124:2447-2455
Inaba, Hiroto; Cao, Xueyuan; Han, Alice Q et al. (2018) Bone mineral density in children with acute lymphoblastic leukemia. Cancer 124:1025-1035
Wilson, Carmen L; Howell, Carrie R; Partin, Robyn E et al. (2018) Influence of fitness on health status among survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer 65:e27286
Mueller, Emily L; Park, Elyse R; Kirchhoff, Anne C et al. (2018) Insurance, chronic health conditions, and utilization of primary and specialty outpatient services: a Childhood Cancer Survivor Study report. J Cancer Surviv 12:639-646

Showing the most recent 10 out of 6764 publications