The Molecular Clinical Trials Shared Resource (MCTSR) is a highly-specialized resource that provides expert advice and technological and experimental support for the conduct of molecular assays of drug targets and drug activity within prospective clinical trials. The MCTSR, collects, processes and analyzes samples from patients treated within prospective clinical trials of molecular targeted therapies. Resource support extends throughout the entire research process from initial study design and planning through to the implementation and interpretation of results. The MCTSR is currently supporting 17 clinical trials within the SJCCC and cooperative groups and is engaging all four SJCCC programs that treat patients. During the current reporting period the resource provided molecular biology services to papers reporting seven Phase I clinical trials and five Phase II studies, of which seven were published in the Journal of Clinical Oncology. The resource contributed major molecular biology services to a further nine papers, including studies published in Nature, Nature Medicine, and Cancer Cell.

Public Health Relevance

The Molecular Clinical Trials Shared Resource provides Center members with access to laboratory research expertise for the conduct of assays of drug target expression and activity in the context of prospective clinical trials. Consequently, the MCTSR has stimulated and facilitated interactions between clinical and laboratory based researchers throughout the Cancer Center. PROJECT/PERFORMANCE SITE(S) (if additional space is needed, use Project

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA021765-39
Application #
9439725
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
39
Fiscal Year
2018
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Shadrick, William R; Slavish, Peter J; Chai, Sergio C et al. (2018) Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors. Bioorg Med Chem 26:25-36
Ramsey, Laura B; Balis, Frank M; O'Brien, Maureen M et al. (2018) Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance. Oncologist 23:52-61
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Hatfield, M Jason; Binder, Randall J; Gannon, Rowan et al. (2018) Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza (""Danshen""). J Nat Prod 81:2410-2418
Vo, BaoHan T; Kwon, Jin Ah; Li, Chunliang et al. (2018) Mouse medulloblastoma driven by CRISPR activation of cellular Myc. Sci Rep 8:8733
Mandrell, Belinda N; Avent, Yvonne; Walker, Breya et al. (2018) In-home salivary melatonin collection: Methodology for children and adolescents. Dev Psychobiol 60:118-122
Drummond, Catherine J; Hanna, Jason A; Garcia, Matthew R et al. (2018) Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors. Cancer Cell 33:108-124.e5
Jones, Conor M; Baker, Justin N; Keesey, Rachel M et al. (2018) Importance ratings on patient-reported outcome items for survivorship care: comparison between pediatric cancer survivors, parents, and clinicians. Qual Life Res 27:1877-1884
Huang, I-Chan; Brinkman, Tara M; Mullins, Larry et al. (2018) Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia. Psychooncology 27:2031-2038
Huang, I-Chan; Klosky, James L; Young, Chelsea M et al. (2018) Misclassification of self-reported smoking in adult survivors of childhood cancer. Pediatr Blood Cancer 65:e27240

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