The mission of the Clinical Research Shared Service (CRSS) is to integrate and facilitate the management. Coordination and conduct of clinical research at the Arizona Cancer Center (AZCC) and to ensure that the clinical trial processes meets local, state, and federal policies and regulations. The following objectives are designed to accomplish this mission: (1) Provide centralized administration and processing of clinical trial documentation via the AZCC Clinical Administration Trials Office;(2) Provide centralized Data Management and Research Nursing services with a focus on Therapeutic trials;(3) Provide pharmacy admixture and inventory maintenance for investigational agents used in peer-review clinical trials in the multidisciplinary clinics;(4) Aid in the development of novel formulations or combinations of agents for investigators performing pilot clinical trials;(5) Oversee and ensure quality control in the conduct of AZCC clinical trials;(6) Implement a web-based clinical trials management system (Oncore?) to facilitate peer-reviewed clinical research initiatives and reporting. Dr. Livingston is the current Director. Ms Ma, the Associate Director of Clinical Trials, assists with day-to-day operations of the CRSS. All clinical research-related documents flow through the AZCC Clinical Trials Office (CTO) for review, processing for further distribution and submission, and/or maintenance in study-specific regulatory files. The CTO also coordinates and provides administrative support for the AZCC Scientific Review Committee (SRC, Protocol Review and Monitoring System). Clinical research activities are accomplished via disease-specific teams consisting of clinical investigators, research nurse, clinical research coordinators/data managers along with regulatory assistants (IRB Coordinators) and other administrative support. The AZCC Data Safety and Monitoring Board (DSMB), chaired by Dr. Dragovich, is responsible for quality assurance/quality control in AZCC clinical trials. AZCC has implemented Oncore? to manage daily clinical research operations. Usage of the CRSS is mainly by AZCC members (77%) and spans most departments and programs. 61% of AZCC member users are with peer reviewed funding. In the period of July 2007-June 2008, The total accrual of therapeutic trials in the four NCI-defined categories is 284.
To integrate and facilitate the coordination and conduct of clinical research (therapeutic, prevention, population science, and translational) at the Arizona Cancer Center (AZCC) and to ensure that the clinical trial process meets local, state, and federal policies and regulations.
|Bea, Jennifer W; Jurutka, Peter W; Hibler, Elizabeth A et al. (2015) Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism 64:447-59|
|Leung, Sarah J; Rice, Photini S; Barton, Jennifer K (2015) In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. Lasers Surg Med 47:40-9|
|Dickinson, Sally E; Rusche, Jadrian J; Bec, Sergiu L et al. (2015) The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog 54:1513-20|
|Quintero-Ramos, A; Gutiérrez-Rubio, S A; Del Toro-Arreola, A et al. (2014) Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population. Genet Mol Res 13:8749-56|
|Landowski, Terry H; Gard, Jaime; Pond, Erika et al. (2014) Targeting integrin ?6 stimulates curative-type bone metastasis lesions in a xenograft model. Mol Cancer Ther 13:1558-66|
|Jiang, Yanlong; Kong, Qingke; Roland, Kenneth L et al. (2014) Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity. Int J Med Microbiol 304:431-43|
|Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45|
|Kang, Hyun-Jin; Kendrick, Samantha; Hecht, Sidney M et al. (2014) The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc 136:4172-85|
|Chow, H-H Sherry; Garland, Linda L; Heckman-Stoddard, Brandy M et al. (2014) A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med 12:223|
|Lancaster, Jordan J; Juneman, Elizabeth; Arnce, Sarah A et al. (2014) An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure. J Heart Lung Transplant 33:438-45|
Showing the most recent 10 out of 852 publications