The primary goal of the Biostatistics Shared Resource is to provide biostatistical and biomathematical support and collaboration for laboratory, translational, clinical, population, and epidemiological cancer studies underway at Huntsman Cancer Institute (HCI). The Biostatistics Resource enhances the scientific quality and sophistication of cancer research projects by providing tailored, professional consultation at all levels and stages of research. The Resource assists investigators with study design, sample size/power calculations, data analyses, grant applications, and manuscripts. Emphasis is placed on early consultation to allow adequate consideration and adaptation of study designs to meet the main objectives of the research. The Resource also provides educational outreach to Cancer Center members as needed, allowing investigators to better address their specific research problems. The Biostatistics Shared Resource, by virtue of its activities with a broad range of cancer investigators, is central to the Cancer Center's priorities. It is also a focal point of transdisciplinary cancer research, as it facilitates the collaborative work of basic, population, and clinical researchers from many departments. The primary research component of the Biostatistics Resource focuses on carcinogenesis modeling, on methodologies for high throughput genomics applicable to cancer pathways (such as microarray, ChlP-Seq, and Digital Gene Expression), and on methodologies for analysis of familial aspects of cancer. Use of this Shared Resource by the Cancer Center has increased substantially during the most recent cycle, and biostaticians have been involved in numerous important scientific discoveries. Kenneth Boucher, PhD, is the Resource Director and reports to HCI Senior Directors. Since the recent receipt of the University of Utah Clinical and Translational Science Award, Biostatistics is also now affiliated with the biostatistical component of that program. The Resource retains direct Cancer Center management, while the affiliation allows increased depth of expertise combined with increased interaction of institutional biostaticians and related academic activities. The Resource also has an established advisory committee, which regularly reviews structure, quality of service and research, as well as goals and needs. The Resource is housed in the HCI research building. In 2008, usage of the Shared Resource by the Cancer Center was 79 percent. Funds are requested from the CCSG to cover 15 percent ($74,806) of the proposed Biostatistics budget. The Resource is currently near capacity, although the 21 percent of non-Center use could be reprioritized to Cancer Center members should the need arise. Additionally, new recruitment efforts should soon add capacity to this Resource.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Utah
Salt Lake City
United States
Zip Code
Albright, Frederick; Stephenson, Robert A; Agarwal, Neeraj et al. (2015) Prostate cancer risk prediction based on complete prostate cancer family history. Prostate 75:390-8
Eiring, A M; Page, B D G; Kraft, I L et al. (2015) Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia. Leukemia 29:586-97
Lerman, Daniel M; Monument, Michael J; McIlvaine, Elizabeth et al. (2015) Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer 62:759-65
Quackenbush, John F; Cassidy, Pamela B; Pfeffer, Lawrence M et al. (2014) Isolation of circulating microRNAs from microvesicles found in human plasma. Methods Mol Biol 1102:641-53
Clark, Kathleen A; Graves, Barbara J (2014) Dual views of SRF: a genomic exposure. Genes Dev 28:926-8
Oakley, Gretchen M; Curtin, Karen; Layfield, Lester et al. (2014) Increased melanoma risk in individuals with papillary thyroid carcinoma. JAMA Otolaryngol Head Neck Surg 140:423-7
Zhang, Rui; Yang, Jiyuan; Sima, Monika et al. (2014) Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates. Proc Natl Acad Sci U S A 111:12181-6
Smith, M A; Hoffman, L M; Beckerle, M C (2014) LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol 24:575-83
Van Vranken, Jonathan G; Bricker, Daniel K; Dephoure, Noah et al. (2014) SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab 20:241-52
Gibson, Summer B; Figueroa, Karla P; Bromberg, Mark B et al. (2014) Familial clustering of ALS in a population-based resource. Neurology 82:17-22

Showing the most recent 10 out of 805 publications