Developmental Funds awarded to the Georgetown Lombardi Comprehensive Cancer Center (LCCC) have been used to support 17 pilot projects and the recruitment of two senior faculty members in areas of strategic need. Pilot projects were solicited on the basis of strategic priorities established through LCCC's Executive Committee and the projects evaluated through a peer-review process. Over this funding cycle, 17 pilot projects were supported by a combination of Developmental Funds and institutional support yielding 215 subsequent publications and $11.16M in external funding (direct costs). Developmental funds supported the recruitment of Deputy Director Michael Atkins, MD, to add expertise in translational clinical trial design, biologic therapy and biomarker development, and to add expertise in melanoma and kidney cancers. Developmental Funds also supported the recruitment of Ming Tan, PhD, to co-lead the Biostatistics &Bioinformatics Shared Resource and. strengthen LCCC's clinical biostatistics research and clinical trial support. Developmental Funds are now requested to support transdisciplinary and translational pilot projects that allow LCCC investigators to pursue innovative ideas and high-priority research areas.
Funding to support pilot projects is critical to develop preliminary data to design and develop hypotheses. It provides a mechanism for the Center to develop concepts that support programmatic themes and to promote transdisciplinary and translational research. Support for critical recruitments of faculty have strengthened areas of strategic priority for the Center.
|Lai, Chih-Hsin; Lai, Ying-Jung J; Chou, Feng-Pai et al. (2016) Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation. PLoS One 11:e0152904|
|AlHossiny, Midrar; Luo, Linlin; Frazier, William R et al. (2016) Ly6E/K Signaling to TGFÎ² Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance. Cancer Res 76:3376-86|
|Chung, Arlene E; Jensen, Roxanne E; Basch, Ethan M (2016) Leveraging Emerging Technologies and the "Internet of Things" to Improve the Quality of Cancer Care. J Oncol Pract 12:863-866|
|Brown, Lindsay; Gutherz, Samuel; Kulick, Catherine et al. (2016) Profile of retigabine-induced neuronal apoptosis in the developing rat brain. Epilepsia 57:660-70|
|Hunegnaw, Ruth; Vassylyeva, Marina; Dubrovsky, Larisa et al. (2016) Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation. Arterioscler Thromb Vasc Biol 36:1758-71|
|Taylor, Kathryn L; Hoffman, Richard M; Davis, Kimberly M et al. (2016) Treatment Preferences for Active Surveillance versus Active Treatment among Men with Low-Risk Prostate Cancer. Cancer Epidemiol Biomarkers Prev 25:1240-50|
|Allen, Megan; Ghosh, Suhasini; Ahern, Gerard P et al. (2016) Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1. Sci Rep 6:35497|
|Boca, Simina M; Nishida, Maki; Harris, Michael et al. (2016) Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study. PLoS One 11:e0153461|
|Spikol, Emma D; Laverriere, Caroline E; Robnett, Maya et al. (2016) Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics. Diseases 4:|
|Cheema, Amrita K; Maier, Irene; Dowdy, Tyrone et al. (2016) Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis. PLoS One 11:e0151190|
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