Developmental Funds awarded to the Georgetown Lombardi Comprehensive Cancer Center (LCCC) have been used to support 17 pilot projects and the recruitment of two senior faculty members in areas of strategic need. Pilot projects were solicited on the basis of strategic priorities established through LCCC's Executive Committee and the projects evaluated through a peer-review process. Over this funding cycle, 17 pilot projects were supported by a combination of Developmental Funds and institutional support yielding 215 subsequent publications and $11.16M in external funding (direct costs). Developmental funds supported the recruitment of Deputy Director Michael Atkins, MD, to add expertise in translational clinical trial design, biologic therapy and biomarker development, and to add expertise in melanoma and kidney cancers. Developmental Funds also supported the recruitment of Ming Tan, PhD, to co-lead the Biostatistics &Bioinformatics Shared Resource and. strengthen LCCC's clinical biostatistics research and clinical trial support. Developmental Funds are now requested to support transdisciplinary and translational pilot projects that allow LCCC investigators to pursue innovative ideas and high-priority research areas.
Funding to support pilot projects is critical to develop preliminary data to design and develop hypotheses. It provides a mechanism for the Center to develop concepts that support programmatic themes and to promote transdisciplinary and translational research. Support for critical recruitments of faculty have strengthened areas of strategic priority for the Center.
|Bae, Woo Kyun; Yoo, Kyung Hyun; Lee, Ji Shin et al. (2015) The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers. Mol Carcinog 54:1172-80|
|Adams, Inez; Christopher, Juleen; Williams, Karen Patricia et al. (2015) What Black Women Know and Want to Know About Counseling and Testing for BRCA1/2. J Cancer Educ 30:344-52|
|Butrick, Morgan; Kelly, Scott; Peshkin, Beth N et al. (2015) Disparities in uptake of BRCA1/2 genetic testing in a randomized trial of telephone counseling. Genet Med 17:467-75|
|London, Laricca; Hurtado-de-Mendoza, Alejandra; Song, Minna et al. (2015) Motivators and barriers to Latinas' participation in clinical trials: the role of contextual factors. Contemp Clin Trials 40:74-80|
|Mays, Darren; Niaura, Raymond S; Evans, W Douglas et al. (2015) Cigarette packaging and health warnings: the impact of plain packaging and message framing on young smokers. Tob Control 24:e87-92|
|Zhi, Xiuling; Lin, Ling; Yang, Shaoxian et al. (2015) ?II-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. Hepatology 61:598-612|
|Rush, Christina L; Darling, Margaret; Elliott, Maria Gloria et al. (2015) Engaging Latina cancer survivors, their caregivers, and community partners in a randomized controlled trial: Nueva Vida intervention. Qual Life Res 24:1107-18|
|Heckler, Mary Mazzotta; Riggins, Rebecca B (2015) ERR? splice variants differentially regulate cell cycle progression. Cell Cycle 14:31-45|
|Kim, B; Wang, S; Lee, J M et al. (2015) Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene 34:1083-93|
|Tong, Angie; Kelly, Scott; Nusbaum, Rachel et al. (2015) Intentions for risk-reducing surgery among high-risk women referred for BRCA1/BRCA2 genetic counseling. Psychooncology 24:33-9|
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