Abstract

In HIV-infected patients treated with HAART, there are variable rates of reconstitution of T cell numbers and function. An understanding of the mechanisms underlying the recovery of T cells will be important for the design of future strategies to improve T cell reconstitution. The thymus is the organ responsible for producing new naive T cells with a broad immune repertoire from bone marrow-derived precursors. IL-7 is a cytokine that has direct effects upon the thymus and naive T cells. This study examines the role of the thymus in HIV infection and immune reconstitution, and how IL-7 can affect that role.This study seeks to improve our understanding of how HAART affects the immune response to HIV, and how therapeutic vaccination, with or without additional interventions, will lead to improved immunity against HIV and better control of virus replication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005013-05
Application #
7299814
Study Section
(VRC)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Hryniewicz, Anna; Price, David A; Moniuszko, Marcin et al. (2007) Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. J Immunol 178:3492-504
Seggewiss, Ruth; Lore, Karin; Guenaga, F Javier et al. (2007) Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110:441-9
Lore, Karin; Seggewiss, Ruth; Guenaga, F Javier et al. (2006) In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques. Stem Cells 24:1539-48
Petrovas, Constantinos; Casazza, Joseph P; Brenchley, Jason M et al. (2006) PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 203:2281-92
Chattopadhyay, Pratip K; Price, David A; Harper, Theresa F et al. (2006) Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nat Med 12:972-7
Maecker, Holden T; Rinfret, Aline; D'Souza, Patricia et al. (2005) Standardization of cytokine flow cytometry assays. BMC Immunol 6:13
Podsakoff, Greg M; Engel, Barbara C; Carbonaro, Denise A et al. (2005) Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Mol Ther 12:77-86
Betts, Michael R; Exley, Barbara; Price, David A et al. (2005) Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proc Natl Acad Sci U S A 102:4512-7
Casazza, Joseph P; Betts, Michael R; Hill, Brenna J et al. (2005) Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy. J Virol 79:3653-63
Golden-Mason, Lucy; Douek, Daniel C; Koup, Richard A et al. (2004) Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development. J Immunol 172:5980-5

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