The central theme of the Developmental Biology (DB) Program is that cancer is often the result of corrupted developmental regulatory networks. We strive to use the powerful molecular genetics available in model organisms to understand fundamental signaling processes underlying normal development, and the abnormalities in these pathways that can lead to cancer. The goal is to provide key new targets for chemopreventive and chemotherapeutic interventions. Program Membership: Since the last renewal, the Developmental Biology Program has undergone several leadership changes. Dr. Bryant stepped down as the program leader to focus on rejuvenating the Graduate Program in Molecular Biology Genetics and Biochemistry and was replaced by Dr. Blumberg. After his stint as Graduate director ended, Dr. Bryant rejoined the program as Co-Leader in 2006 and was replaced by Dr. Marsh in 2007. Drs. Bode and Fallon retired and Dr. Brachmann transitioned to Associate Member. New Members include Dr. Maike Sander who moved from GF, and Drs. Peter Donovan, Taosheng Huang, Tom Schilling, and Rahul Warrior who joined the Program. The DB Program has 16 Members, representing five Departments and two Schools, and has $5,019,083 in direct cancer-related peer-reviewed funding, 1 project of which is funded by NCI for a direct total of $152,000. In 2007, Members published a total of 28 publications with 18 of those being cancer-related of which 22% were inter- and 6% were intra-related.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-18
Application #
8740827
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-09-11
Project End
2014-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
18
Fiscal Year
2013
Total Cost
$15,079
Indirect Cost
$5,558
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Cox-Muranami, Wesley A; Nelson, Edward L; Li, G P et al. (2016) Large area magnetic micropallet arrays for cell colony sorting. Lab Chip 16:172-81
Klempner, Samuel J; Gershenhorn, Bruce; Tran, Phu et al. (2016) BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy. Cancer Discov 6:594-600
Li, N; Pasricha, S; Bulsiewicz, W J et al. (2016) Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation Registry. Dis Esophagus 29:537-43
Nolen, Shantell C; Lee, Brian; Shantharam, Shruti et al. (2016) The effects of sequential treatments on hippocampal volumes in malignant glioma patients. J Neurooncol 129:433-41
Bota, Daniela A; Davies, Kelvin J A (2016) Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med 100:188-198
Pedram, Ali; Razandi, Mahnaz; Blumberg, Bruce et al. (2016) Membrane and nuclear estrogen receptor α collaborate to suppress adipogenesis but not triglyceride content. FASEB J 30:230-40
Greene, Christina L; Worrell, Stephanie G; Attwood, Stephen E et al. (2016) Emerging Concepts for the Endoscopic Management of Superficial Esophageal Adenocarcinoma. J Gastrointest Surg 20:851-60
Iyer, Neel S; Osann, Kathryn; Hsieh, Susie et al. (2016) Health Behaviors in Cervical Cancer Survivors and Associations with Quality of Life. Clin Ther 38:467-75
Leproux, Anaïs; Kim, You Me; Min, Jun Won et al. (2016) Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging. J Biomed Opt 21:74001
McLaren, Christine E; Barton, James C; Subramaniam, V Nathan et al. (2016) Reply. Hepatology 63:2058-60

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