Abstract

The Cancer Center DMA Sequencing Core operates as a recharge facility to provide access to leading edge automated DMA sequence analysis. Investigators conduct their own sequencing reactions which are then run on ABI3100 sequencers for $2.50/sample. All data entry and retrieval is conducted by direct internet access for Member convenience. This user/core """"""""co-op"""""""" format was adopted to 1) maximize throughput for the majority of Cancer Center users, 2) supply a reduced cost service not commercially available, and 3) provide training for future researchers, a primary function of a University. Approximately 15,000-20,000 reactions a year, from over 190 different users/Pis are analyzed. The majority of users are Cancer Center Members.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-18
Application #
8740835
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-09-11
Project End
2014-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
18
Fiscal Year
2013
Total Cost
$46,770
Indirect Cost
$16,221

  Institution

Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Qiu, Xiaolong; Huang, Jen-Huang; Westerhof, Trisha M et al. (2018) Microfluidic channel optimization to improve hydrodynamic dissociation of cell aggregates and tissue. Sci Rep 8:2774
Zhu, Yong; Wang, Xiuye; Forouzmand, Elmira et al. (2018) Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Mol Cell 69:62-74.e4
Mishra, Birendra; Lawson, Gregory W; Ripperdan, Ryan et al. (2018) Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors. Radiat Res 190:142-150
Song, Wan; Zsindely, Nóra; Faragó, Anikó et al. (2018) Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease. Hum Mol Genet 27:649-666
Lin, Xiaoxiao; Itoga, Christy A; Taha, Sharif et al. (2018) c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress. Neurobiol Stress 8:92-102
Kim, Chang Soo; Ingato, Dominique; Wilder-Smith, Petra et al. (2018) Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography. Nano Converg 5:3
Chakraborty, Mahul; VanKuren, Nicholas W; Zhao, Roy et al. (2018) Hidden genetic variation shapes the structure of functional elements in Drosophila. Nat Genet 50:20-25
Morozko, Eva L; Ochaba, Joseph; Hernandez, Sarah J et al. (2018) Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice. J Huntingtons Dis 7:321-335
Carpenter, Philip M; Ziogas, Argyrios; Markham, Emma M et al. (2018) Laminin 332 expression and prognosis in breast cancer. Hum Pathol 82:289-296

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