Abstract

This application proposes to study functional MRI, structural MRI, and neuropsychological function in individuals at different levels of risk for Alzheimer's Disease. The risk groups will be defined by family history and by apolipoprotein-E allele status. The major hypothesis is that the pattern and extent of cortical activation during a visual confrontation naming task will differ substantially between subjects at high and low risk for AD. The investigators will also determine whether structural/anatomic differences exist between the groups and whether these MRI findings correlate with neuropsychological function. This application addresses a very important area in AD research. The preliminary fMRI data would be stronger if it included elderly subjects or these at risk for AD. The use of two different strategies for identifying intermediate risk groups may pose some difficulties and interpretation. The primary analyses of fMRI data is group mean data rather date released: 04/04/1997.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036660-03
Application #
2892290
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Murphy, Diane
Project Start
1997-09-30
Project End
2001-05-31
Budget Start
1999-06-01
Budget End
2001-05-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Kentucky
Department
Neurology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Smith, Charles D (2012) Structural imaging in early pre-states of dementia. Biochim Biophys Acta 1822:317-24
Gold, Brian T; Johnson, Nathan F; Powell, David K et al. (2012) White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim Biophys Acta 1822:416-22
Andersen, Anders H; Rayens, William S; Liu, Yushu et al. (2012) Partial least squares for discrimination in fMRI data. Magn Reson Imaging 30:446-52
Smith, Charles D; Chebrolu, Himachandra; Andersen, Anders H et al. (2010) White matter diffusion alterations in normal women at risk of Alzheimer's disease. Neurobiol Aging 31:1122-31
Martin, Sarah B; Smith, Charles D; Collins, Heather R et al. (2010) Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging 31:1099-106
Gold, Brian T; Powell, David K; Andersen, Anders H et al. (2010) Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease. Neuroimage 52:1487-94
Smith, Charles D; Lori, Nicolas F; Akbudak, Erbil et al. (2009) MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans. J Magn Reson Imaging 29:1248-61
Conturo, Thomas E; Williams, Diane L; Smith, Charles D et al. (2008) Neuronal fiber pathway abnormalities in autism: an initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways. J Int Neuropsychol Soc 14:933-46
Liu, Xun; Steinmetz, Nicholas A; Farley, Alison B et al. (2008) Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions. J Cogn Neurosci 20:1711-26
Smith, C D; Chebrolu, H; Wekstein, D R et al. (2007) Brain structural alterations before mild cognitive impairment. Neurology 68:1268-73

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