8.3.1 ABSTRACT: GENETIC MECHANISMS OF CANCER The Genetic Mechanisms of Cancer program, lead by David Largaespada, has 40 members, representing ten departments and three schools. As of September 30,2007, these members have a total of $10.9 million in peer-reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 234 publications, of which 17% were intra-prograrnmatic and 15% were inter-programmatic. The Genetic Mechanisms of Cancer research program focuses on gene discovery, stability, expression, and transfer. - . . '? ?;. . ... . Dr. Largaespada is the Margaret Harvey Schering Land Grant Chair in Cancer Genetics. He is the director of the Mouse Genetics Laboratory shared resource of the Cancer Center. As chair of the Rodent Advisory Committee, he plays a role in advising the Academic Health Center on issues related to mouse and rat work at the University of Minnesota. He is a member of the NCI-sponsored Mouse Models of Human Cancer Consortium. The program also includes scientists with leadership positions in clinical research. Dr. Robert Kratzke, who is the Vice Chair of the Respiratory Committee of the Cancer and Leukemia Group B T (CALGB), as well as Chair of the Respiratory Working Group (RWG) for Correlative Sciences. Dr. Robert Madoff is on the gastrointestinal subcommittee of the CALGB and board of directors of the Minnesota Colorectal Cancer Initiative. Other program members have important leadership roles within the University of Minnesota. Dr. Brian Van Ness is the chair of the Department of Genetics, Cell Biology and Development. Dr. Scott Selleck is the director of the Developmental Biology Center. Dr. Harry Orr js the Tulloch Professor of Genetics, the director of the Institute of Human Genetics (IHG), and a Special Advisor to the Dean of the Medical School on basic science matters. Dr.
J aim e Modiano is the director of the Animal Cancer Center in the Veterinary Medical Center and holds the Al and June Perlman Endowed Chair in Animal Oncology.

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Pang, Jiuxia; Shen, Na; Yan, Fei et al. (2017) Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8:34453-34467
Lin, Weiming; Modiano, Jaime F; Ito, Daisuke (2017) Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci 18:101-104
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Zhao, Xianda; Li, Lihua; Starr, Timothy K et al. (2017) Tumor location impacts immune response in mouse models of colon cancer. Oncotarget 8:54775-54787
Lynn, Geoffrey E; Oliver, Jonathan D; Cornax, Ingrid et al. (2017) Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent. Parasit Vectors 10:48
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Boylan, Kristin L M; Buchanan, Petra C; Manion, Rory D et al. (2017) The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8:9717-9738
Mallhi, K; Orchard, P J; Miller, W P et al. (2017) Non-myeloablative conditioning for second hematopoietic cell transplantation for graft failure in patients with non-malignant disorders: a prospective study and review of the literature. Bone Marrow Transplant 52:726-732
Richardson, Paul G; Smith, Angela R; Triplett, Brandon M et al. (2017) Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. Br J Haematol 178:112-118

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