The goal of the Cancer Prevention and Population Sciences (CPPS) Program is to reduce the incidence and impact of cancer by conducting innovative multidisciplinary cancer prevention and population sciences research. The CPPS Program has 31 research members from a multiple Departments at Baylor, including Medicine, Pediatrics, Surgery, Urology, Psychiatry, and Neuroscience. These include 5 new members whose recruitment to Baylor was facilitated by the Cancer Center;in addition, 6 Baylor investigators in the biobehavioral aspects of nicotine dependence have joined CPPS. The program had $4,561,452 support from the NCI last year and overall received $10,035,029 in peer reviewed funding. Members of the program published over 300 cancer related manuscripts in peer-reviewed journals of which 29% were intraprogrammatic collaborations and 12% interprogrammatic. Our program is conceptually organized into two broad thematic areas: (1) Cancer Epidemiology and Genetics: CPPS Investigators conduct studies to examine the etiology of childhood and adulthood cancers, and to study the contribution of gene and gene environment interactions to their etiology;and to identify the clinical and molecular characteristics of syndromes that result in hereditary predisposition to cancers. Other CPPS investigators evaluate the cancer outcomes especially to address health disparities and inequities in access, treatment, and survival. Major accomplishments include analyses of secular trends and risk factors for several digestive and liver cancers, identification of genetic polymorphisms that are associated with risk of childhood and adult tumors as well as for premalignant lesions such as Barrett's esophagus and liver cirrhosis, (2) Biobehavioral Research and Cancer Prevention: This theme is focused on Childhood Obesity and Physical Activity, in which investigators study the determinants of obesity and physical activity in children and adolescents, and evaluate culturally appropriate interventions;Nicotine Dependence in which investigators examine the genetics of addictive behavior, in both animal models and human studies, and to evaluate novel interventions for smoking cessation;and Chemoprevention research to test novel prevention agents in animals and in human trials. Major accomplishments in this theme include the development of interventional programs to improve childhood diet and exercise to combat childhood obesity, the role of genetics in nicotine dependence through study of nicotinic receptors, and the conduct of breast cancer prevention clinical trials.

Public Health Relevance

This program consists of epidemiologists and outcomes researchers as well as basic and translational scientists who focus their research efforts on preventing cancer by understanding its etiology and outcomes, of cancer as well as of the main risk factors for cancer (e.g., obesity and smoking).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA125123-08
Application #
8690545
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77030
Badr, Hoda; Herbert, Krista; Bonnen, Mark D et al. (2018) Dyadic Coping in Patients Undergoing Radiotherapy for Head and Neck Cancer and Their Spouses. Front Psychol 9:1780
Morita, Daisuke; Nishio, Nobuhiro; Saito, Shoji et al. (2018) Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells. Mol Ther Methods Clin Dev 8:131-140
Bajgain, Pradip; Tawinwung, Supannikar; D'Elia, Lindsey et al. (2018) CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation. J Immunother Cancer 6:34
Ballester, Leomar Y; Lu, Guangrong; Zorofchian, Soheil et al. (2018) Analysis of cerebrospinal fluid metabolites in patients with primary or metastatic central nervous system tumors. Acta Neuropathol Commun 6:85
Bollard, Catherine M; Tripic, Tamara; Cruz, Conrad Russell et al. (2018) Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma. J Clin Oncol 36:1128-1139
Gates, Leah A; Gu, Guowei; Chen, Yue et al. (2018) Proteomic profiling identifies key coactivators utilized by mutant ER? proteins as potential new therapeutic targets. Oncogene 37:4581-4598
Dasgupta, Subhamoy; Rajapakshe, Kimal; Zhu, Bokai et al. (2018) Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature 556:249-254
Qin, Liying; Sankaran, Banumathi; Aminzai, Sahar et al. (2018) Structural basis for selective inhibition of human PKG I? by the balanol-like compound N46. J Biol Chem 293:10985-10992
Shi, Xiangguo; Kitano, Ayumi; Jiang, Yajian et al. (2018) Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells. Exp Hematol 64:33-44.e5
Disney-Hogg, Linden; Cornish, Alex J; Sud, Amit et al. (2018) Impact of atopy on risk of glioma: a Mendelian randomisation study. BMC Med 16:42

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