The University of Kansas Cancer Center (KUCC) has established biospecimen banking activities to coordinate the ethical collection, storage, annotation, and distribution of tissue and peripheral blood samples to support translational research. This center-wide activity is overseen by an inter-programmatic Internal Advisory Board (I AB), under the recent supervision of Andrew K. Godwin within the Department of Pathology and Laboratory Medicine. The BSR has three major functions: 1) identify participants, administer informed consent, collect tissue, blood, and/or urine samples from selected populations, and obtain information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research;2) process and house human biospecimens obtained through investigator-initiated studies;and 3) provide expert histology technical procedures and pathological evaluation of tissue samples. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specially trained staff obtain patient consent, collect samples and assemble comprehensive clinical information about each donor and the corresponding samples. As part of this banking the BSR staff provides i) outstanding diagnostic pathology support;ii) a comprehensive informed consent process for the use of tissue, blood, and/or urine from patients and participants for research;iii) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research;iv) extensive supporting data from the clinical record and self-reported health history of each participant, and v) fixation, paraffin processing, slide preparation and routine staining, immunohistochemistry support, tissue microarray, image analysis and digital pathology. All specimens will be linked to comprehensive clinical databases supported by the Biostatistics and Informatics Shared Resource. The BSR currently houses over 2,000 cases with fresh-frozen tissue samples and over 2,000 cases with blood samples and has access to over 28,000 surgical pathology cases on file. In 2010 the BSR served 16 (Q peer-reviewed funded) KUCC investigators across the four programs, including distribution of 382 fresh and fresh-frozen specimens, 666 units of activity to support investigator-initiated studies, and 3,105 units of histotechnology services. 47.4% of the BSR's use in 2010 was by peer-reviewed funded investigators.

Public Health Relevance

Translational research requires access to appropriately consented and well-characterized human biosamples. Therefore, facilities such as the BSR are essential to the mission of a comprehensive cancer center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA168524-03
Application #
8702114
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$44,237
Indirect Cost
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Walker, Logan C; Marquart, Louise; Pearson, John F et al. (2017) Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. Eur J Hum Genet 25:432-438
Lal, Shruti; Cheung, Edwin C; Zarei, Mahsa et al. (2017) CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol Cancer Res 15:696-707
Xiao, Lifu; Tian, Xiumei; Harihar, Sitaram et al. (2017) Gd2O3-doped silica @ Au nanoparticles for in vitro imaging cancer biomarkers using surface-enhanced Raman scattering. Spectrochim Acta A Mol Biomol Spectrosc 181:218-225
Pessetto, Ziyan Y; Chen, Bin; Alturkmani, Hani et al. (2017) In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. Oncotarget 8:4079-4095
Wolfe, Andy R; Ernlund, Amanda; McGuinness, William et al. (2017) Suppression of intestinal tumorigenesis in Apc mutant mice upon Musashi-1 deletion. J Cell Sci 130:805-813
Sasaki, Ken; Kurahara, Hiroshi; Young, Eric D et al. (2017) Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer. Clin Exp Metastasis 34:229-239
New, Jacob; Arnold, Levi; Ananth, Megha et al. (2017) Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target. Cancer Res 77:6679-6691
Brinker, Amanda E; Vivian, Carolyn J; Koestler, Devin C et al. (2017) Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver-Dependent Manner. Cancer Res 77:6941-6949
Do, Thuy-Vy; Hirst, Jeff; Hyter, Stephen et al. (2017) Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells. Oncotarget 8:50376-50392
Spaw, Mark; Anant, Shrikant; Thomas, Sufi Mary (2017) Stromal contributions to the carcinogenic process. Mol Carcinog 56:1199-1213

Showing the most recent 10 out of 135 publications