This renewal application for a K24 seeks to continue to provide time for the candidate, Jennifer Friedman, MD, PhD, to provide mentorship to junior faculty in patient oriented research (POR) with a focus on optimizing interventions for parasitic diseases among pregnant women and children. The second goal is to provide time for Dr. Friedman to further her own career development through a) pursuit of advanced education in Structural Equation Modeling and characterization of the human microbiome and b) leading policy changes to include pregnant women and young children in treatment programs for schistosomiasis. Dr. Friedman proposes to continue to mentor junior faculty and fellows conducting POR at the Center for International Health Research (CIHR). The Center is an outstanding model for interdisciplinary team science, where most faculty are physician-scientists and other scientists carry out translational research as an integral part of these teams. In the first phase of this K24, Dr. Friedman closely mentored five junior faculty at CIHR. Of these, four were recipients of Career Development Awards with Dr. Friedman as primary or co-mentor and the other was a target young investigator on a large training grant (Centers for Biomedical Research Excellence (COBRE)) in infectious diseases. In addition, one mentee (Levine) received his first independent grants (R03 and R01) in 2017 with grant writing mentorship provided by Dr. Friedman. The overarching scientific goal of this proposal is to advance studies elucidating mechanisms through which schistosomiasis contributes to environmental enteropathy, culminating in microbial translocation, systemic immune activation, and adverse pregnancy and nutritional outcomes. Dr. Friedman has two current R01s that provide outstanding opportunities for junior faculty to conduct POR in global health. The first is a longitudinal birth cohort (PIs Friedman, Gundogan) that has already enrolled N=400 pregnant women and is now following the newborns until age two. The second is a multi-site RCT (PIs Friedman, Bustinduy) examining optimal dose and dosing frequency of praziquantel for children under the age of four. Both grants provide both opportunities to conduct field work at sites with longstanding collaborations and will offer a wealth of well characterized data and samples to address the aims proposed in this K24 as well as other aims conceived of by mentees. They will also be able to engage in other NIH grants at CIHR with co-mentoring by Dr. Friedman and other faculty (see letters of support). Brown University affiliated hospitals provide a rich source of potential mentees from a range of Divisions housing junior faculty interested in conducting POR in infectious diseases. In addition, although there are numerous other training grants at Brown affiliates, there are two T32 awards, two COBRE awards, and one R25, which could specifically provide a pipeline for young investigators and co-funding in research areas of interest to Dr. Friedman.

Public Health Relevance

The goals of this proposal are to provide time for the candidate to provide mentorship to junior faculty conducting patient-oriented research in global health, with a focus on optimizing interventions for parasitic diseases of pregnancy and early childhood.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Gondre-Lewis, Timothy A
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Rhode Island Hospital
United States
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Friedman, Jennifer F; Olveda, Remigio M; Mirochnick, Mark H et al. (2018) Praziquantel for the treatment of schistosomiasis during human pregnancy. Bull World Health Organ 96:59-65
Abioye, Ajibola I; Park, Sangshin; Ripp, Kelsey et al. (2018) Anemia of Inflammation during Human Pregnancy Does Not Affect Newborn Iron Endowment. J Nutr 148:427-436
Park, Sangshin; Srikiatkhachorn, Anon; Kalayanarooj, Siripen et al. (2018) Use of structural equation models to predict dengue illness phenotype. PLoS Negl Trop Dis 12:e0006799
Kurtis, Jonathan D; Raj, Dipak K; Michelow, Ian C et al. (2018) Maternally derived antibodies to Schizont Egress Antigen-1 and protection of infants from severe malaria. Clin Infect Dis :
McDonald, Emily A; Stuart, Ronald; Joshi, Ayush et al. (2018) Endotoxin at the Maternal-Fetal Interface in a Resource-Constrained Setting: Risk Factors and Associated Birth Outcomes. Am J Trop Med Hyg 99:495-501
Bustinduy, Amaya L; Stothard, J Russell; Friedman, Jennifer F (2017) Paediatric and maternal schistosomiasis: shifting the paradigms. Br Med Bull 123:115-125
Nixon, Christina E; Park, Sangshin; Pond-Tor, Sunthorn et al. (2017) Identification of Protective B-Cell Epitopes within the Novel Malaria Vaccine Candidate Plasmodium falciparum Schizont Egress Antigen 1. Clin Vaccine Immunol 24:
Park, Sangshin; Bellinger, David C; Adamo, Meredith et al. (2016) Mechanistic Pathways From Early Gestation Through Infancy and Neurodevelopment. Pediatrics 138:
Blake, Rachel A; Park, Sangshin; Baltazar, Palmera et al. (2016) LBW and SGA Impact Longitudinal Growth and Nutritional Status of Filipino Infants. PLoS One 11:e0159461
Bustinduy, Amaya L; Friedman, Jennifer F; Kjetland, Eyrun Floerecke et al. (2016) Expanding Praziquantel (PZQ) Access beyond Mass Drug Administration Programs: Paving a Way Forward for a Pediatric PZQ Formulation for Schistosomiasis. PLoS Negl Trop Dis 10:e0004946