The primary expertise of Monell investigators spans a wide range of disciplines, including human sensory physiology and psychophysics (Drs. Breslin, Cowart, Dalton, Lundstrom, Pelchat, Mennella, Wysocki. Yamazaki. and Zhao), mouse and/or rat genefics (Drs. Bachmanov, Reed, and Tordoff), molecular biology (Drs. Brand, Margolskee, and Huang), and animal chemosensory physiology (Drs. Beauchamp, Lowe, Margolskee, and Reisert). Most or all of these research programs use DNA or RNA analysis methods at various fimes, but these methods often lie outside their area of expertise. This Core will serve to remove barriers from the invesfigators'use of these techniques. For instance, transgenic mice used by laboratories that study mouse behavior and physiology need to be genotyped to ensure that they are of the correct group (e.g., knockout or wild-type), but the invesfigator has no training in genotyping methods. Therefore, it is useful for the investigator to have a technician available who has been rigorously trained by experts to perform this work, to make use ofthe equipment available in the Core. Thus, not all people who study genefically engineered mice need to have all the equipment to genotype mice in their own laboratories. Likewise, invesfigators doing human sensory work might like to know their subject's genotype for key sensory polymorphisms (e.g., is the person homozygous for certain alleles associated with bitter taste blindness?). Again, this is often outside the expertise of their laboratory, but by working with this Core they can receive appropriate training and readily collect these data. Thus, this Core will provide a centralized common resource and reservoir of experience in genotyping and DNA/RNA analysis that would be inefficient to replicate in each individual laboratory. The availability of Core services extends the capabilifies of the participafing laboratories beyond what each could do individually.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC011735-03
Application #
8491773
Study Section
Special Emphasis Panel (ZDC1-SRB-Q)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$128,561
Indirect Cost
$40,433
Name
Monell Chemical Senses Center
Department
Type
DUNS #
088812565
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Yamaguchi, Tatsuya; Yamashita, Junpei; Ohmoto, Makoto et al. (2014) Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. BMC Neurosci 15:13
Tordoff, Michael G; Ellis, Hillary T; Aleman, Tiffany R et al. (2014) Salty taste deficits in CALHM1 knockout mice. Chem Senses 39:515-28
Tordoff, Michael G; Downing, Arnelle; Voznesenskaya, Anna (2014) Macronutrient selection by seven inbred mouse strains and three taste-related knockout strains. Physiol Behav 135:49-54
Kokrashvili, Zaza; Yee, Karen K; Ilegems, Erwin et al. (2014) Endocrine taste cells. Br J Nutr 111 Suppl 1:S23-9
Feng, Pu; Huang, Liquan; Wang, Hong (2014) Taste bud homeostasis in health, disease, and aging. Chem Senses 39:3-16
Parker, M Rockwell; Feng, Dianna; Chamuris, Brianna et al. (2014) Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells. Neurosci Lett 571:72-7
Mennella, Julie A; Reed, Danielle R; Roberts, Kristi M et al. (2014) Age-related differences in bitter taste and efficacy of bitter blockers. PLoS One 9:e103107
van Valkenburgh, Blaire; Pang, Benison; Bird, Deborah et al. (2014) Respiratory and olfactory turbinals in feliform and caniform carnivorans: the influence of snout length. Anat Rec (Hoboken) 297:2065-79
Mennella, Julie A; Finkbeiner, Susana; Lipchock, Sarah V et al. (2014) Preferences for salty and sweet tastes are elevated and related to each other during childhood. PLoS One 9:e92201
Adappa, Nithin D; Zhang, Zi; Palmer, James N et al. (2014) The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol 4:3-7

Showing the most recent 10 out of 33 publications