HDDC Brief Overview - Research Focus The Harvard Digestive Disease Center is focused on the cell biology and function of epithelial cells of the alimentary tract, liver, and pancreas, and the complex interactions of epithelia with the microbial flora and subepithelial cells of the lamina propria that manifests itself in mucosal immunity and allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract. The biology of epithelial cells and their interactions with subepithelial tissues dictates organ function in the Gl tract and explains how the host relies upon and yet defends against components of the natural environment including food and non-nutrient antigens, the commensal and pathogenic microbial flora, toxins, and microbial products. Development and maintenance of this complex system requires rapidly adaptive mechanisms for cross-talk among the epithelial cells lining the mucosa surface, immunocompetent and supporting cell types in the sub-epithelial space, and the environment. The title of our Center, "Integrated Epithelial and Mucosal Biology" reflects this research focus. This emphasis on the epithelial cell and its mucosal environment reflects the historical and contemporary strengths of the Harvard Digestive Disease Center and provides a unifying focus for scientists with interests in the diverse functions of the gastrointestinal tract. The Center aims to facilitate multidisciplinary research in this field by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in Boston's Longwood Medical Area. We also aim to recruit new and established investigators to the field. Our overarching mission is to foster and expand basic and translational science in fields related to digestive diseases by: connecting people, creating opportunity, and extending resources.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034854-29
Application #
8578082
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
29
Fiscal Year
2014
Total Cost
$373,637
Indirect Cost
$54,026
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Jirapinyo, Pichamol; Dayyeh, Barham K Abu; Thompson, Christopher C (2016) Gastrojejunal anastomotic reduction for weight regain in roux-en-y gastric bypass patients: physiological, behavioral, and anatomical effects of endoscopic suturing and sclerotherapy. Surg Obes Relat Dis 12:1810-1816
Ariyachet, Chaiyaboot; Tovaglieri, Alessio; Xiang, Guanjue et al. (2016) Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell Stem Cell 18:410-21
Mudde, Anne C A; Lexmond, Willem S; Blumberg, Richard S et al. (2016) Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models. World Allergy Organ J 9:23
Arabzadeh, Azadeh; Dupaul-Chicoine, Jeremy; Breton, Valérie et al. (2016) Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells. Gut 65:821-9
Magalhães, Ana Cristina; Ferreira, Ana Rita; Gomes, Sílvia et al. (2016) Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response. Sci Rep 6:26028
Bucci, Vanni; Tzen, Belinda; Li, Ning et al. (2016) MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses. Genome Biol 17:121
Duncan, Daniel R; Amirault, Janine; Johnston, Nikki et al. (2016) Gastroesophageal Reflux Burden, Even in Children That Aspirate, Does Not Increase Pediatric Hospitalization. J Pediatr Gastroenterol Nutr 63:210-7
Gensollen, Thomas; Iyer, Shankar S; Kasper, Dennis L et al. (2016) How colonization by microbiota in early life shapes the immune system. Science 352:539-44
Mingozzi, Francesca; Spreafico, Roberto; Gorletta, Tatiana et al. (2016) Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors. EMBO Mol Med 8:1039-51
Cox, Andrew G; Hwang, Katie L; Brown, Kristin K et al. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol 18:886-96

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