The overall goal of the Interventions and Translation Core (ITC) is to provide expertise and infrastructure to assist investigators with the development, implementation, and evaluation of culturally appropriate interventions. Our objective is to create new knowledge regarding the prevention and management of diabetes and cardiometabolic disease, with an emphasis on reducing health disparities. The ITC?s 3 specific aims are to: 1. Provide expert consultation for intervention development in diabetes prevention and management (e.g., interventions to optimize diet, body weight, exercise/physical activity, medication adherence, and/or glycemic control). This expertise will facilitate translation of basic science findings into efficacy-testing interventions ranging from clinical to community-based trials. 2. Provide expertise on study design and evaluation, including measurement, quality control, quality assurance, and analytic support, for research to prevent and manage diabetes. These studies will include but also go beyond traditional clinical trials. For example, group-randomized trials evaluating weight-loss interventions in community settings require specialized expertise in trial design, data capture and transfer, as well as in interventional and analytic tools. 3. Design and facilitate culturally appropriate strategies to enhance the recruitment and retention of minorities and underserved populations in diabetes-related research studies, with emphasis on African American and rural communities. These core services are based on the expressed needs of funded DRC investigators, and methods will rely on validated, state-of-the-art approaches with a high priority placed on data quality control. The ITC will leverage existing infrastructure for recruitment and community-based research and make cutting edge expertise in intervention development, implementation, and evaluation available to the DRC research base, promoting innovation and advancing the science of diabetes prevention and management.

Public Health Relevance

Research to bridge the gap that separates scientific discovery from clinical practice is sorely needed to counter the diabetes epidemic and improve diabetes related health outcomes.The ITC will provide resources and cutting edge expertise in intervention development, implementation and evaluation for researchers at UAB, to define optimal strategies for diabetes care and prevention in the heart of the Deep South.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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University of Alabama Birmingham
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Jones, Kristian T; Shelton, Richard C; Wan, Jun et al. (2016) Impact of acute psychological stress on cardiovascular risk factors in face of insulin resistance. Stress 19:585-592
Wende, Adam R; Young, Martin E; Chatham, John et al. (2016) Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radic Biol Med 100:94-107
Goldsby, TaShauna U; George, Brandon J; Yeager, Valerie A et al. (2016) Urban Park Development and Pediatric Obesity Rates: A Quasi-Experiment Using Electronic Health Record Data. Int J Environ Res Public Health 13:411
Hong, Kyunghee; Xu, Guanlan; Grayson, Truman B et al. (2016) Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. J Biol Chem 291:8428-39
Howard, George; Moy, Claudia S; Howard, Virginia J et al. (2016) Where to Focus Efforts to Reduce the Black-White Disparity in Stroke Mortality: Incidence Versus Case Fatality? Stroke 47:1893-8
Sweatt, S Katherine; Roy, Jane; Chandler-Laney, Paula et al. (2016) Ethnic differences in the consistency and accuracy of perceived exertion. Am J Hum Biol 28:398-404
Cunningham, Glenn R; Stephens-Shields, Alisa J; Rosen, Raymond C et al. (2016) Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels. J Clin Endocrinol Metab 101:3096-104
Cardel, M I; Johnson, S L; Beck, J et al. (2016) The effects of experimentally manipulated social status on acute eating behavior: A randomized, crossover pilot study. Physiol Behav 162:93-101
Krzywanski, David M; Moellering, Douglas R; Westbrook, David G et al. (2016) Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet 9:26-36
Quon, Bradley S; Rowe, Steven M (2016) New and emerging targeted therapies for cystic fibrosis. BMJ 352:i859

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