The overall goal of the Interventions and Translation Core (ITC) is to provide expertise and infrastructure to assist investigators with the development, implementation, and evaluation of culturally appropriate interventions. Our objective is to create new knowledge regarding the prevention and management of diabetes and cardiometabolic disease, with an emphasis on reducing health disparities. The ITC?s 3 specific aims are to: 1. Provide expert consultation for intervention development in diabetes prevention and management (e.g., interventions to optimize diet, body weight, exercise/physical activity, medication adherence, and/or glycemic control). This expertise will facilitate translation of basic science findings into efficacy-testing interventions ranging from clinical to community-based trials. 2. Provide expertise on study design and evaluation, including measurement, quality control, quality assurance, and analytic support, for research to prevent and manage diabetes. These studies will include but also go beyond traditional clinical trials. For example, group-randomized trials evaluating weight-loss interventions in community settings require specialized expertise in trial design, data capture and transfer, as well as in interventional and analytic tools. 3. Design and facilitate culturally appropriate strategies to enhance the recruitment and retention of minorities and underserved populations in diabetes-related research studies, with emphasis on African American and rural communities. These core services are based on the expressed needs of funded DRC investigators, and methods will rely on validated, state-of-the-art approaches with a high priority placed on data quality control. The ITC will leverage existing infrastructure for recruitment and community-based research and make cutting edge expertise in intervention development, implementation, and evaluation available to the DRC research base, promoting innovation and advancing the science of diabetes prevention and management.

Public Health Relevance

Research to bridge the gap that separates scientific discovery from clinical practice is sorely needed to counter the diabetes epidemic and improve diabetes related health outcomes.The ITC will provide resources and cutting edge expertise in intervention development, implementation and evaluation for researchers at UAB, to define optimal strategies for diabetes care and prevention in the heart of the Deep South.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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University of Alabama Birmingham
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Birur, Badari; Shelton, Richard C; Amrock, Ellen M et al. (2017) Response to: Commentary: Sex Differences in the Peripheral Immune System in Patients with Depression. Front Psychiatry 8:231
Akinyemiju, Tomi; Ogunsina, Kemi; Okwali, Michelle et al. (2017) Lifecourse socioeconomic status and cancer-related risk factors: Analysis of the WHO study on global ageing and adult health (SAGE). Int J Cancer 140:777-787
Li, Li; Garvey, W Timothy; Gower, Barbara A (2017) Childhood Maltreatment Is an Independent Risk Factor for Prediabetic Disturbances in Glucose Regulation. Front Endocrinol (Lausanne) 8:151
Carter, Stephen J; Plaisance, Eric P; Fisher, Gordon et al. (2017) Alterations in Hemoglobin and Serum 25-hydroxyvitamin D are Related Before and After Weight Loss Independent of African Admixture. Int J Sport Nutr Exerc Metab 27:59-66
Budoff, Matthew J; Ellenberg, Susan S; Lewis, Cora E et al. (2017) Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. JAMA 317:708-716
Prigge, Justin R; Coppo, Lucia; Martin, Sebastin S et al. (2017) Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Rep 19:2771-2781
Piccinini, Francesca; Polidori, David C; Gower, Barbara A et al. (2017) Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women. Diabetes 66:2564-2570
Resnick, Susan M; Matsumoto, Alvin M; Stephens-Shields, Alisa J et al. (2017) Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment. JAMA 317:717-727
Barbour, S E; Ramanadham, S (2017) Analyses of Calcium-Independent Phospholipase A2beta (iPLA2?) in Biological Systems. Methods Enzymol 583:119-141
Warren, Jonathan L; Bulur, Sule; Ovalle, Fernando et al. (2017) Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women. Metabolism 77:1-12

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