Animal Phenotyping Core A thereugh understanding ef the precesses centrelling the response te nutrients and ef the mechanisms that centribute te obesity and related metabolic diseases is required if we are te effectively combat these condifions. The detailed analysis of animals with altered metabolism (e.g. due te dietary, molecular, genefic, or pharmacological manipulation) at a level that reveals basic underiying mechanisms of control requires specialized expertise and technology not normally available to individual investigators. Established in 2006, the goals efthe MNORC Animal Phenotyping Cere was are te provide state-of-the art equipment, services and censultafive advice regarding the detailed metabolic phenotyping of rodent models of metabolic diseases. The Animal Phenotyping Core makes the metabolic analysis of rodent models of disease available, expedifious, affordable, effective, and convenient for individual investigators. In addition to providing educafion, consultation and advice regarding the analysis ef rat and mouse models with altered metabolism, the Core provides phenotyping services on specialized equipment that it operates. Specifically, the cere determines body eempesitien and utilizes the CLAMS apparatus and other systems to examine metabolic rate, respiratory quotient, food consumption, and acfivity in rodent models ef metabolic disease. The Cere also examines the response te exercise and examines cardiovascular and ether parameters by telemetry in rodents. The Core performs hyperinsulinemic/euglycemic clamp studies including specialized analysis ef metabolite storage and release in rats and mice, as well as providing catheterizafion/cannulafien services and fissue harvesting in rodents. Thus, overall, the Animal Phenotyping Core will consultatively aid individual investigators in designing an appropriate experimental plan for the metabolic analysis of animal models relevant to obesity and then provide the tools and services necessary to effect this analysis. This research is relevant to public health because it will increase our understanding ef the events that underiie the development ef obesity and its complications, and hence will facilitate the develepment ef improved diagnostic, prevenfion and treatment strategies.

Public Health Relevance

Obesity has become a national problem that has defied easy treatment. The Animal Phenotyping Core of the Michigan Nutrition Obesity Research Center will provide investigators with advanced phenotyping techniques to understand the response to nutrition and/or other mechanisms that underlie obesity and alterations in metabolism in rodent models of disease. These insights will enable the design of novel dietary, exercise and medication interventions to control obesity and obesity-related diseases

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK089503-05
Application #
8688230
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Weinhouse, Caren; Sartor, Maureen A; Faulk, Christopher et al. (2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environ Mol Mutagen 57:435-46
Stromsdorfer, Kelly L; Yamaguchi, Shintaro; Yoon, Myeong Jin et al. (2016) NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell Rep 16:1851-60
Eswaran, Shanti L; Chey, William D; Han-Markey, Theresa et al. (2016) A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D. Am J Gastroenterol 111:1824-1832
Sondhi, Varun; Owen, Bryn M; Liu, Jiayan et al. (2016) Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells. Mol Endocrinol 30:469-78
Sidahmed, ElKhansa; Sen, Ananda; Ren, Jianwei et al. (2016) Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. Nutr Cancer 68:1192-201
Sas, Kelli M; Kayampilly, Pradeep; Byun, Jaeman et al. (2016) Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. JCI Insight 1:e86976
Chhabra, Kavaljit H; Adams, Jessica M; Jones, Graham L et al. (2016) Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity. Mol Metab 5:869-81
Morris, David L; Oatmen, Kelsie E; Mergian, Taleen A et al. (2016) CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity. J Leukoc Biol 99:1107-19
Shaeib, Faten; Khan, Sana N; Thakur, Mili et al. (2016) The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality. PLoS One 11:e0151160
Greenwald-Yarnell, Megan L; Marsh, Courtney; Allison, Margaret B et al. (2016) ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology 157:1555-65

Showing the most recent 10 out of 235 publications