The Engineering &Translational Imaging (E&TI) Module is the newly redesigned Image Analysis Module that also encompasses functions of our former Animal Resources Module. The re-development and melding of Module functions was recommended by our Core Advisory Committee to reflect the changing emphases in Module use, to take better advantage of the exceptional skills of our existing personnel, and to accommodate the research interests of new members added to our group. We consider the new Module highly innovative. We also believe it will spur innovative research because of its emphasis on technology development. This Module is expected to be unusually important for fostering collaboration between those who develop new imaging technologies and those who use them - including the clinical faculty in ophthalmology - to everyone's benefit. Our former Animal Resources Module provided shared space located within the school's animal care area that is outfitted with equipment dedicated to performing ophthalmic examinations and procedures on research animals. This essential function is retained, but moved into the E&TI Module for two compelling reasons: (1) the animal area is increasingly used for retinal imaging and functional analyses of animal eyes (rather than for procedures), which is precisely parallel to the human subjects imaging supported by the former Image Analysis Module (now renamed the E&TI), and (2) the former Animal Resource Module had no support staff. Our newly designed E&TI Module will have an expanded role for the Module assistant who aids with studies of human subjects to include studies of research animals. The Module will also have an engineer to maintain existing instruments, modify them to suit investigators'needs, and - importantly - to develop new instruments and new image processing and data analysis software. This Module staffing will bring significantly added value to those who do animal research. Further, the translational aspect of our Core investigators'research will be strongly supported by melding support for animal and human eye imaging under the same Module umbrella. The highly innovative and well integrated functions of the newly designed E&TI Module therefore are: (1) to provide engineering support for maintaining, modifying and developing novel imaging technologies, (2) to assist with generating and analyzing images of animal and human eyes, both for testing new devices and for studying ocular phenotypes, and (3) to facilitate studies involving imaging of human subjects in collaboration with clinician scientists through the services of a Module assistant who functions as clinical research coordinator. This Module is expected to significantly enhance productivity and provide important cost benefits by making available equipment and services that could not be supported on individual investigator's grants including specialized imaging instruments, an engineer skilled in working on optical devices, and a clinical research coordinator to facilitate human subjects research.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical College of Wisconsin
United States
Zip Code
Land, Megan E; Cooper, Robert F; Young, Jonathon et al. (2014) Cone structure in subjects with known genetic relative risk for AMD. Optom Vis Sci 91:939-49
Dubow, Michael; Pinhas, Alexander; Shah, Nishit et al. (2014) Classification of human retinal microaneurysms using adaptive optics scanning light ophthalmoscope fluorescein angiography. Invest Ophthalmol Vis Sci 55:1299-309
Wilk, Melissa A; McAllister, John T; Cooper, Robert F et al. (2014) Relationship between foveal cone specialization and pit morphology in albinism. Invest Ophthalmol Vis Sci 55:4186-98
Flatter, John A; Cooper, Robert F; Dubow, Michael J et al. (2014) Outer retinal structure after closed-globe blunt ocular trauma. Retina 34:2133-46
Dubis, Adam M; Cooper, Robert F; Aboshiha, Jonathan et al. (2014) Genotype-dependent variability in residual cone structure in achromatopsia: toward developing metrics for assessing cone health. Invest Ophthalmol Vis Sci 55:7303-11
Langlo, Christopher S; Flatter, John A; Dubra, Alfredo et al. (2014) A lensing effect of inner retinal cysts on images of the photoreceptor mosaic. Retina 34:421-2
Sulai, Yusufu N; Scoles, Drew; Harvey, Zachary et al. (2014) Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope. J Opt Soc Am A Opt Image Sci Vis 31:569-79
Scoles, Drew; Higgins, Brian P; Cooper, Robert F et al. (2014) Microscopic inner retinal hyper-reflective phenotypes in retinal and neurologic disease. Invest Ophthalmol Vis Sci 55:4015-29
Scoles, Drew; Sulai, Yusufu N; Langlo, Christopher S et al. (2014) In vivo imaging of human cone photoreceptor inner segments. Invest Ophthalmol Vis Sci 55:4244-51
Zareba, Mariusz; Skumatz, Christine M B; Sarna, Tadeusz J et al. (2014) Photic injury to cultured RPE varies among individual cells in proportion to their endogenous lipofuscin content as modulated by their melanosome content. Invest Ophthalmol Vis Sci 55:4982-90

Showing the most recent 10 out of 379 publications