NEI-supported investigators from Duke University and their collaborators from the University of North Carolina at Chapel Hill (UNC) request continuing support for a Center Core Grant for Vision Research. Research areas covered by this group range from deciphering basic mechanisms of signal transduction in rod and cone photoreceptors to delineating functional organization of the visual cortex, and from identifying disease genes to finding effective therapy for common eye disorders. For the past 25 years, we have used the NEI Core Grant to develop and update our resource modules, thus enhancing the capabilities of individual NEI-supported investigators and our institutions to conduct vision research. The Core Grant effectively provides (1) shared resources and services that are not readily supported by individual research grants and (2) an atmosphere conducive to sharing current techniques and ideas;both are critical to the successful research of individual investigators. Furthermore, the infrastructure created to support this grant facilitates the participation of clinical ophthalmologists at Duke in vision research, and especially the development of clinician scientists, thereby supporting and facilitating the translation of the discoveries from basic research into new diagnostic and therapeutic applications directly related to human eye diseases. We request support for three existing and one new resource modules: Morphology/Image Processing Module, Mass Spectrometry/Molecular Biology Module, Animal Models Module and Genetics/Bioinformatics Module. Support of these shared resources is vital to the creation of synergy that will give impetus to our vision research group in reaching a level of success that is greater than the sum of the individual investigator's expected achievements.

Public Health Relevance

This grant supports facility infrastructure that enhances the capability of individual laboratories to address pathobiology, molecular mechanisms, genetic predisposition and outcomes of several blinding diseases, including but not limited to: age-related macular degeneration, glaucoma, retinitis pigmentosa and dry eye. This grant also provides collaborative environment critical for productive interactions between basic and clinician scientists and for raising next generation of researchers.

National Institute of Health (NIH)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
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Duke University
Schools of Medicine
United States
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Srinivasan, Pratul P; Heflin, Stephanie J; Izatt, Joseph A et al. (2014) Automatic segmentation of up to ten layer boundaries in SD-OCT images of the mouse retina with and without missing layers due to pathology. Biomed Opt Express 5:348-65
Farsiu, Sina; Chiu, Stephanie J; O'Connell, Rachelle V et al. (2014) Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography. Ophthalmology 121:162-72
Malek, Goldis (2014) Nuclear receptors as potential therapeutic targets for age-related macular degeneration. Adv Exp Med Biol 801:317-21
Porter, Kristine M; Jeyabalan, Nallathambi; Liton, Paloma B (2014) MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. Biochim Biophys Acta 1843:1054-62
Xu, Ping; Lin, Yizhi; Porter, Kristine et al. (2014) Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther 30:246-53
Malek, Goldis; Lad, Eleonora M (2014) Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. Cell Mol Life Sci 71:4617-36
O'Brien, E Timothy; Wang, Yanhong; Ying, Hongyu et al. (2014) Differential expression of genes in cells cultured from juxtacanalicular trabecular meshwork and Schlemm's canal. J Ocul Pharmacol Ther 30:291-9
Pearring, Jillian N; Lieu, Eric C; Winter, Joan R et al. (2014) R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. Mol Biol Cell 25:2644-9
Patil, Hemangi; Saha, Arjun; Senda, Eugene et al. (2014) Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. J Biol Chem 289:29767-89
Yang, Ping; Baciu, Peter; Kerrigan, Brittany C Parker et al. (2014) Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. Invest Ophthalmol Vis Sci 55:3012-21

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