The overall objective of the Laboratory-based Core of the Center for Oral Health Research (L-COHR) is to provide MUSC researchers with a unified Core that provides access to methodologies and guidance on research project planning and implementation for studies using complex tissues, specialized microbial flora, and environment of the oral cavity. To achieve this objective, the L-COHR is composed of four distinct but interactive facilities: 1) Oral Cancer Research Facility, 2) Laser Capture Microdissection Facility, 3) Gnotobiotic Animal Research Facility, and 4) Mineralized Tissue Facility. Collectively, these facilities provide researchers with a full spectrum of services and expertise including the generation and use of mouse models in pathogen-free conditions, mouse models of tumor progression, cellular and molecular analysis of tumor and tissue samples, and the analysis of mineralized tissues and associated pathologies. L-COHR was conceived and initiated during the second phase of COBRE funding due to a new cadre of investigators at MUSC with expanded research needs and recognition of gaps in available services on campus for techniques and approaches used in oral health research. The Director of L-COHR is an established, highly respected scientist and educator with responsibilities for oversight of all Core activities including services, education, training and outreach. Each of the four facilities is directed by expert faculty;L-COHR is also staffed by five trained and experienced research and animal technicians who assist in the daily operations of each facility and L-COHR as a whole. Overall, L-COHR has compiled essential resources and expertise to assist researchers with their projects in the areas of microbial pathogenesis, oral cancer and mineralized tissue research. The services offered by the Core are either novel methodologies within the University or procedures that require expertise to generate meaningful data. The Core will benefit the Center members by providing a unified facility to conduct and analyze these complex experiments and offer advice and training in research related to the Center goals. Additionally, the Core will continue to offer new services to the University research community and improve our overall research efforts.
Oral diseases and craniofacial disorders are linked to total health and wellbeing throughout life. Virtually everyone has had at least one oral disease, e.g., dental caries, periodontal disease, cold sores or cancer. Many suffer from oral and facial pain. General risk factors, such as tobacco use and poor dietary practices, affect oral/craniofacial health and data show a connection between oral health and chronic illnesses such as diabetes and cancer. The national health expenditures for dental services exceeded $102 billion in 2009.
|Valerio, Michael S; Herbert, Bethany A; Basilakos, Dimitrios S et al. (2015) Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine 71:71-80|
|Jin, J; Machado, E R; Yu, H et al. (2014) Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. J Dent Res 93:294-9|
|Hunt, Kelly J; Kistner-Griffin, Emily; Spruill, Ida et al. (2014) Cardiovascular risk in Gullah African Americans with high familial risk of type 2 diabetes mellitus: project SuGAR. South Med J 107:607-14|
|Intini, G; Katsuragi, Y; Kirkwood, K L et al. (2014) Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions. Adv Dent Res 26:38-46|
|Talwar, Sudha; House, Reniqua; Sundaramurthy, Santhanalakshmi et al. (2014) Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR. J Biol Chem 289:3487-500|
|Zhang, Lumin; Luo, Zhenwu; Sieg, Scott F et al. (2014) Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis. J Virol 88:11430-41|
|He, Huacheng; Cattran, Alexander W; Nguyen, Tu et al. (2014) Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials 35:9546-53|
|Valerio, Michael S; Herbert, Bethany A; Griffin 3rd, Alfred C et al. (2014) MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation. Bone 60:16-25|
|Zhang, Xiaoyi; Hyer, J Madison; Yu, Hong et al. (2014) DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma. Cancer Res 74:7191-7|
|Travan, Suncica; Li, Fei; D'Silva, Nisha J et al. (2013) Differential expression of mitogen activating protein kinases in periodontitis. J Clin Periodontol 40:757-64|
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