The administrative and mentoring Core is responsible for the overall coordination of activities associated with the COBRE and the Tulane Hypertension and Renal Center of Excellence (THRCE). This involves interactions with departments in the School of Medicine (Medicine, Pediatrics, Physiology, Pharmacology), the School of Public Health and Tropical Medicine (Epidemiology) and the School of Science and Engineering (Biomedical Engineering, Neurosciences). The members of our COBRE in Hypertension and Renal Biology have progressively increased their extramural research support, publications of peer reviewed papers, and presentations at national and international meetings. The efforts have been coordinated by the administrative Core of the COBRE which has been responsible for keeping track of all accomplishments. Under the direction of PI, Dr. L. G. Navar, the program coordinator. Dr. L. Hamm, and the program administrator, Nina R. Majid, the Administrative and Mentoring Core will coordinate and facilitate all the research and training activities supported by the COBRE Cores and Pilot Projects. Accordingly, the Administrative Core will: 1) Provide overall leadership to the COBRE personnel by serving as a resource to the intellectual and mentoring activities of the center. 2) Coordinate and enhance mentoring and research training for career development of COBRE investigators. 3) Provide competent, efficient, and timely oversight of financial activities of the Research Cores and Pilot projects. 4) Enrich the intellectual environment of the Center through regularly scheduled seminars and conferences, support of external consultants, special courses, and various workshops. 5) Encourage multidisciplinary and translational projects by facilitating interactions among investigators from different departments and components of the university. 6) Schedule and organize meetings and activities of the internal steering committee (ISC) and the External Advisory Committee (EAC). 7) Administer all requisite activities of the pilot project grants program. Through the efficient accomplishment and implementation of these varied responsibilities, the administrative and Mentoring Core will provide direction, stability, and leadership to the Phase III program.

Public Health Relevance

Hypertension is a leading cause of death and disability affecting over 50 million people in the United States and responsible for 200,000 deaths annually. The link between hypertension and the kidneys is because many forms of hypertension result from abnormalities in kidney function due either to primary or congenital renal disease or to abnormal hormonal or environmental influences that affect renal function leading to progressive renal and vascular injury.

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National Institute of General Medical Sciences (NIGMS)
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Liu, Liu; Kashyap, Shreya; Murphy, Brennah et al. (2016) GPER activation ameliorates aortic remodeling induced by salt-sensitive hypertension. Am J Physiol Heart Circ Physiol 310:H953-61
Hsu, Raymond K; Chai, Boyang; Roy, Jason A et al. (2016) Abrupt Decline in Kidney Function Before Initiating Hemodialysis and All-Cause Mortality: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 68:193-202
Pingili, Ajeeth K; Thirunavukkarasu, Shyamala; Kara, Mehmet et al. (2016) 6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice. Hypertension 67:916-26
Denburg, Michelle R; Hoofnagle, Andrew N; Sayed, Samir et al. (2016) Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D-Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations Across Genotypes. J Bone Miner Res 31:1128-36
Osis, Gunars; Handlogten, Mary E; Lee, Hyun-Wook et al. (2016) Effect of NBCe1 deletion on renal citrate and 2-oxoglutarate handling. Physiol Rep 4:
Anwar, Imran J; Miyata, Kayoko; Zsombok, Andrea (2016) Brain stem as a target site for the metabolic side effects of olanzapine. J Neurophysiol 115:1389-98
Navar, L Gabriel (2016) 2016 Young Investigator Award of the American Physiological Society Renal Section. Am J Physiol Renal Physiol :ajprenal.00133.2016
Rocco, Michael V; Chapman, Arlene; Chertow, Glenn M et al. (2016) Chronic Kidney Disease Classification in Systolic Blood Pressure Intervention Trial: Comparison Using Modification of Diet in Renal Disease and CKD-Epidemiology Collaboration Definitions. Am J Nephrol 44:130-40
Navaneethan, Sankar D; Roy, Jason; Tao, Kelvin et al. (2016) Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in CKD. J Am Soc Nephrol 27:877-86
Amdur, Richard L; Feldman, Harold I; Gupta, Jayanta et al. (2016) Inflammation and Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol 11:1546-56

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