The goal of this revised PSO grant is to expand the present COBRE-funded Kentucky Spinal Cord Injury Research Center (KSCIRC) Core facilities at the University of Louisville (UofL). We propose to broaden the scope of research that these Cores support in neural development and CNS injury, and 2) bring additional PIs into the Center both to enhance their research programs and to bring their new techniques and approaches to the COBRE PIs. We will increase the number of involved PIs from 8 to 22. The Cores will facilitate the research programs of both NIH funded and non-funded junior and more senior PIs in directions that would not be possible without the highly trained Core personnel. Each Core will be directed by a funded PI and housed in independent, dedicated laboratory space. All PIs will have access to these Cores. We will give priority access to junior and unfunded PIs. The UofL administration will make significant space and financial commitment to the COBRE/KSCIRC Core Facilities. The Cores are: A) Administration and Biostatistics, B) Surgery and Animal Care, C) Behavioral and Electrophysiological Assessment, D) Cell and Tissue Imaging and Histology, and E) Human Translational Studies.
The specific aims are: 1. Support and enhance the scope of the strong ongoing UofL NINDS and non-NINDS funded research in the areas of nervous system injury and repair, including our continuing development of innovative technology. 2. Make our technologies available to additional UofL neuroscientists working in other areas of nervous system development and repair to facilitate their individual research programs with novel approaches. 3. Facilitate the development of the research programs of junior and more senior unfunded Investigators. 4. Enhance collaborative opportunities between PIs that utilize these Core facilities.

Public Health Relevance

Each year, over 10,000 people in the United States suffer a traumatic spinal cord injury (SCI) and a recent estimate puts the number of people living with paralysis in the U.S. at 6 million. SCI continues to be a significant cause of disability and mortality. This grant proposes infrastructure that will allow insight into both mechanisms of injury and repair and novel rehabilitative strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103507-03
Application #
8511735
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Zlotnik, Hinda
Project Start
2011-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$1,042,368
Indirect Cost
$347,456
Name
University of Louisville
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Slomnicki, Lukasz P; Hallgren, Justin; Vashishta, Aruna et al. (2018) Proapoptotic Requirement of Ribosomal Protein L11 in Ribosomal Stress-Challenged Cortical Neurons. Mol Neurobiol 55:538-553
Singh, Goutam; Behrman, Andrea L; Aslan, Sevda C et al. (2018) Respiratory functional and motor control deficits in children with spinal cord injury. Respir Physiol Neurobiol 247:174-180
Aslan, Sevda C; Legg Ditterline, Bonnie E; Park, Michael C et al. (2018) Epidural Spinal Cord Stimulation of Lumbosacral Networks Modulates Arterial Blood Pressure in Individuals With Spinal Cord Injury-Induced Cardiovascular Deficits. Front Physiol 9:565
Vashishta, Aruna; Slomnicki, Lukasz P; Pietrzak, Maciej et al. (2018) RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. Mol Neurobiol 55:8374-8387
Legg Ditterline, Bonnie E; Aslan, Sevda C; Randall, David C et al. (2018) Effects of Respiratory Training on Heart Rate Variability and Baroreflex Sensitivity in Individuals With Chronic Spinal Cord Injury. Arch Phys Med Rehabil 99:423-432
Avila, Diana V; Myers, Scott A; Zhang, JingWen et al. (2017) Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology 125:376-385
Liu, Yulong; Shields, Lisa B E; Gao, Zhongwen et al. (2017) Current Understanding of Platelet-Activating Factor Signaling in Central Nervous System Diseases. Mol Neurobiol 54:5563-5572
Gozal, Evelyne; Metz, Cynthia J; Dematteis, Maurice et al. (2017) PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells. Toxicol Lett 279:107-114
Slomnicki, Lukasz P; Chung, Dong-Hoon; Parker, Austin et al. (2017) Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus. Sci Rep 7:16652
Tang, Tao; Rios-Pilier, Jennifer; Krimm, Robin (2017) Taste bud-derived BDNF maintains innervation of a subset of TrkB-expressing gustatory nerve fibers. Mol Cell Neurosci 82:195-203

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