The goal of this revised PSO grant is to expand the present COBRE-funded Kentucky Spinal Cord Injury Research Center (KSCIRC) Core facilities at the University of Louisville (UofL). We propose to broaden the scope of research that these Cores support in neural development and CNS injury, and 2) bring additional PIs into the Center both to enhance their research programs and to bring their new techniques and approaches to the COBRE PIs. We will increase the number of involved PIs from 8 to 22. The Cores will facilitate the research programs of both NIH funded and non-funded junior and more senior PIs in directions that would not be possible without the highly trained Core personnel. Each Core will be directed by a funded PI and housed in independent, dedicated laboratory space. All PIs will have access to these Cores. We will give priority access to junior and unfunded PIs. The UofL administration will make significant space and financial commitment to the COBRE/KSCIRC Core Facilities. The Cores are: A) Administration and Biostatistics, B) Surgery and Animal Care, C) Behavioral and Electrophysiological Assessment, D) Cell and Tissue Imaging and Histology, and E) Human Translational Studies.
The specific aims are: 1. Support and enhance the scope of the strong ongoing UofL NINDS and non-NINDS funded research in the areas of nervous system injury and repair, including our continuing development of innovative technology. 2. Make our technologies available to additional UofL neuroscientists working in other areas of nervous system development and repair to facilitate their individual research programs with novel approaches. 3. Facilitate the development of the research programs of junior and more senior unfunded Investigators. 4. Enhance collaborative opportunities between PIs that utilize these Core facilities.

Public Health Relevance

Each year, over 10,000 people in the United States suffer a traumatic spinal cord injury (SCI) and a recent estimate puts the number of people living with paralysis in the U.S. at 6 million. SCI continues to be a significant cause of disability and mortality. This grant proposes infrastructure that will allow insight into both mechanisms of injury and repair and novel rehabilitative strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103507-03
Application #
8511735
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Zlotnik, Hinda
Project Start
2011-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$1,042,368
Indirect Cost
$347,456
Name
University of Louisville
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Aslan, Sevda C; Randall, David C; Krassioukov, Andrei V et al. (2016) Respiratory Training Improves Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury. Arch Phys Med Rehabil 97:964-73
Slomnicki, Lukasz P; Pietrzak, Maciej; Vashishta, Aruna et al. (2016) Requirement of Neuronal Ribosome Synthesis for Growth and Maintenance of the Dendritic Tree. J Biol Chem 291:5721-39
Legg Ditterline, Bonnie E; Aslan, Sevda C; Randall, David C et al. (2016) Baroreceptor reflex during forced expiratory maneuvers in individuals with chronic spinal cord injury. Respir Physiol Neurobiol 229:65-70
Ewan, Eric E; Hagg, Theo (2016) Intrathecal Acetyl-L-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats. J Neurotrauma 33:269-77
Mondello, S E; Jefferson, S C; O'Steen, W A et al. (2016) Enhancing Fluorogold-based neural tract tracing. J Neurosci Methods 270:85-91
Biggs, Bradley T; Tang, Tao; Krimm, Robin F (2016) Insulin-Like Growth Factors Are Expressed in the Taste System, but Do Not Maintain Adult Taste Buds. PLoS One 11:e0148315
Kuypers, Nicholas J; Bankston, Andrew N; Howard, Russell M et al. (2016) Remyelinating Oligodendrocyte Precursor Cell miRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation. J Neurosci 36:1698-710
Myers, Scott A; Bankston, Andrew N; Burke, Darlene A et al. (2016) Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials? Exp Neurol 283:560-72
Pietrzak, Maciej; Rempala, Grzegorz A; Nelson, Peter T et al. (2016) Non-random distribution of methyl-CpG sites and non-CpG methylation in the human rDNA promoter identified by next generation bisulfite sequencing. Gene 585:35-43
Rau, Kristofer K; Hill, Caitlin E; Harrison, Benjamin J et al. (2016) Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons. Exp Neurol 283:413-27

Showing the most recent 10 out of 72 publications