The two overlapping thematic research areas ofthe Centerfor Experimental Infectious Disease Research (CEIDR) have been vector-borne infectious diseases and immunopathogenesis of infectious diseases. We foresee that 5-7 additional faculty will be hired, including joint appointments between the LSU School of Veterinary Medicine (LSU-SVM) and the Tulane National Primate Research Center (TNPRC), during the next five years. To facilitate the main goal of achieving a critical mass of NIH-funded investigators, the Phase III COBRE application includes a Research Pilot Project Program that has a two-fold purpose. Firstly, it will provide funding for junior investigators who will pursue initial research efforts under the mentorship of two senior CEIDR investigators, as with the COBRE phases I and II. These pilot projects will be monitored and evaluated by the Intemal Scientific Advisory Committee (ISAC), the Extemal Advisory Committee (EAC) and the Administrative Core (AC). Secondly, the pilot project program will provide for additional collaborative research efforts between LSU and TNPRC-based scientists working in "shared" principal investigator arrangements. The main goal ofthe pilot research program is to rapidly increase the number of ROI applications and amount of NIH funding through strong mentoring of new investigators and financial support of collaborative projects that have high potential for NIH funding. All pilot projects w receive priority for core support services providing each project with strong research tools to help them succeed within the one year allotted to each pilot project. A second year of pilot funding will only be considered after review by the ISAC, EAC and AC for projects that accomplish outstanding results, as evidenced by recent publications on the subject matter of each pilot, or that have received review of a NIH-submitted application that scores within 10 percentile points of funding. We anticipate the funding of two collaborative projects at $75,000 each and two pilot projects at $50,000 annually. Core charges for each pilot project will be subsidized at 50% of cost. This strategy will sustain core equipment and services by involving new investigators who are expected to continue using these facilities as they succeed in obtaining extramural funding on a fee-for-service basis.

Public Health Relevance

The Pilot Research Program aims to 1) to attract new research projects led by junior investigators who show exceptional promise for developing independent research programs at either LSU or TNPRC, 2) to promote additional collaborations between LSU and TNPRC scientists resulting in shared ROI applications and NIH program project grants utilizing resources of both institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110760-01
Application #
8751078
Study Section
Special Emphasis Panel (ZGM1-TWD-C (3C))
Project Start
2014-06-02
Project End
2019-04-30
Budget Start
2014-06-02
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$370,000
Indirect Cost
$120,000
Name
Louisiana State University A&M Col Baton Rouge
Department
Type
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Verhoeve, Victoria I; Jirakanwisal, Krit; Utsuki, Tadanobu et al. (2016) Differential Rickettsial Transcription in Bloodfeeding and Non-Bloodfeeding Arthropod Hosts. PLoS One 11:e0163769
Riley, Sean P; Fish, Abigail I; Garza, Daniel A et al. (2016) Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection. Infect Immun 84:790-7
Jambunathan, Nithya; Charles, Anu-Susan; Subramanian, Ramesh et al. (2016) Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons. J Virol 90:2230-9
Shen, Li; Macnaughtan, Megan A; Frohlich, Kyla M et al. (2015) Multipart Chaperone-Effector Recognition in the Type III Secretion System of Chlamydia trachomatis. J Biol Chem 290:28141-55
Kaushal, Deepak; Foreman, Taylor W; Gautam, Uma S et al. (2015) Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis. Nat Commun 6:8533
Stanfield, Brent; Kousoulas, Konstantin Gus (2015) Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections. Curr Clin Microbiol Rep 2:125-136
Baños-Lara, Ma Del Rocío; Harvey, Lindsey; Mendoza, Alexander et al. (2015) Impact and regulation of lambda interferon response in human metapneumovirus infection. J Virol 89:730-42
Charles, Anu-Susan; Chouljenko, Vladimir N; Jambunathan, Nithya et al. (2014) Phenylalanine residues at the carboxyl terminus of the herpes simplex virus 1 UL20 membrane protein regulate cytoplasmic virion envelopment and infectious virus production. J Virol 88:7618-27
McCracken, M K; Christofferson, R C; Grasperge, B J et al. (2014) Aedes aegypti salivary protein "aegyptin" co-inoculation modulates dengue virus infection in the vertebrate host. Virology 468-470:133-9
Gillespie, Joseph J; Driscoll, Timothy P; Verhoeve, Victoria I et al. (2014) Genomic diversification in strains of Rickettsia felis Isolated from different arthropods. Genome Biol Evol 7:35-56

Showing the most recent 10 out of 12 publications