The two overlapping thematic research areas ofthe Centerfor Experimental Infectious Disease Research (CEIDR) have been vector-borne infectious diseases and immunopathogenesis of infectious diseases. We foresee that 5-7 additional faculty will be hired, including joint appointments between the LSU School of Veterinary Medicine (LSU-SVM) and the Tulane National Primate Research Center (TNPRC), during the next five years. To facilitate the main goal of achieving a critical mass of NIH-funded investigators, the Phase III COBRE application includes a Research Pilot Project Program that has a two-fold purpose. Firstly, it will provide funding for junior investigators who will pursue initial research efforts under the mentorship of two senior CEIDR investigators, as with the COBRE phases I and II. These pilot projects will be monitored and evaluated by the Intemal Scientific Advisory Committee (ISAC), the Extemal Advisory Committee (EAC) and the Administrative Core (AC). Secondly, the pilot project program will provide for additional collaborative research efforts between LSU and TNPRC-based scientists working in """"""""shared"""""""" principal investigator arrangements. The main goal ofthe pilot research program is to rapidly increase the number of ROI applications and amount of NIH funding through strong mentoring of new investigators and financial support of collaborative projects that have high potential for NIH funding. All pilot projects w receive priority for core support services providing each project with strong research tools to help them succeed within the one year allotted to each pilot project. A second year of pilot funding will only be considered after review by the ISAC, EAC and AC for projects that accomplish outstanding results, as evidenced by recent publications on the subject matter of each pilot, or that have received review of a NIH-submitted application that scores within 10 percentile points of funding. We anticipate the funding of two collaborative projects at $75,000 each and two pilot projects at $50,000 annually. Core charges for each pilot project will be subsidized at 50% of cost. This strategy will sustain core equipment and services by involving new investigators who are expected to continue using these facilities as they succeed in obtaining extramural funding on a fee-for-service basis.
The Pilot Research Program aims to 1) to attract new research projects led by junior investigators who show exceptional promise for developing independent research programs at either LSU or TNPRC, 2) to promote additional collaborations between LSU and TNPRC scientists resulting in shared ROI applications and NIH program project grants utilizing resources of both institutions.
|Gautam, Uma S; Foreman, Taylor W; Bucsan, Allison N et al. (2018) In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 115:E62-E71|
|Huang, Weishan; Solouki, Sabrina; Carter, Chavez et al. (2018) Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages. Front Immunol 9:2625|
|Baños-Lara, Ma Del Rocio; Zabaleta, Jovanny; Garai, Jone et al. (2018) Comparative analysis of miRNA profile in human dendritic cells infected with respiratory syncytial virus and human metapneumovirus. BMC Res Notes 11:432|
|Yang, Kui; Dang, Xiaoqun; Baines, Joel D (2017) A Domain of Herpes Simplex Virus pUL33 Required To Release Monomeric Viral Genomes from Cleaved Concatemeric DNA. J Virol 91:|
|Riley, Sean P; Pruneau, Ludovic; Martinez, Juan J (2017) Evaluation of changes to the Rickettsia rickettsii transcriptome during mammalian infection. PLoS One 12:e0182290|
|Cheemarla, Nagarjuna R; Guerrero-Plata, Antonieta (2017) Human Metapneumovirus Attachment Protein Contributes to Neutrophil Recruitment into the Airways of Infected Mice. Viruses 9:|
|Stanfield, Brent A; Pahar, Bapi; Chouljenko, Vladimir N et al. (2017) Vaccination of rhesus macaques with the live-attenuated HSV-1 vaccine VC2 stimulates the proliferation of mucosal T cells and germinal center responses resulting in sustained production of highly neutralizing antibodies. Vaccine 35:536-543|
|Foreman, Taylor W; Veatch, Ashley V; LoBato, Denae N et al. (2017) Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection. Am J Pathol 187:2811-2820|
|Lewis, Brandon W; Sultana, Razia; Sharma, Rahul et al. (2017) Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease. J Immunol 199:1170-1183|
|Riley, Sean P; Fish, Abigail I; Garza, Daniel A et al. (2016) Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection. Infect Immun 84:790-7|
Showing the most recent 10 out of 24 publications