Abstract

The COBRE for Perinatal Biology is transitioning to a self-supported independent Center for Perinatal Biology during Phase III. In keeping with the thematic focus of the COBRE for Perinatal Biology, we will continue pursuit of research areas that investigate the outcomes of pregnancy and neonatal development. Our research has been driven by recognition that the fundamental mechanisms that regulate embryonic development, cancer, and aging are similar. Insights discerned during developmental stages inform those other periods. The success of our projects has been enhanced by the common view that looking through the ?prism of development? provides not only those insights but, in some instances, experimental leverage and testable hypotheses for how regulatory pathways are governed later in life. Based on the success of Phase I & Phase II, the goals of this COBRE Phase III are to complete the establishment of a nationally recognized Center for Perinatal Biology at Women & Infants Hospital, and to transition to a self-supported, sustainable Center in five years. The primary objective of the Pilot Project Program is to expand and train the pool of investigators in the field of Perinatal Biology. . The Pilot Grants Project Program has the following Specific Aims:
Specific Aim 1 : Provide pilot awards for research projects that will enhance and stimulate collaborative research in perinatal biology and increase use of the Research Core facilities.
Specific Aim 2 : Recruit, mentor and train talented new investigators to the field of Perinatal Biology and provide educational opportunities that will enhance and foster new collaborations within the Program and across multiple Departments, Centers, and Institutions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM114750-01
Application #
8882697
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2015-05-18
Budget End
2016-04-30
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code

  Publications

Chen, Xiaodi; Patra, Aparna; Sadowska, Grazyna B et al. (2018) Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain. Dev Neurosci 40:234-245
Cheng, Shi-Bin; Davis, Sarah; Sharma, Surendra (2018) Maternal-fetal cross talk through cell-free fetal DNA, telomere shortening, microchimerism, and inflammation. Am J Reprod Immunol 79:e12851
Neale, Matthew N; Glass, Kyle A; Longley, Sarah J et al. (2018) Role of the inducible adhesin, CpAls7, in binding of Candida parapsilosis to extracellular matrix under fluid shear. Infect Immun :
Jhun, Bong Sook; O-Uchi, Jin; Adaniya, Stephanie M et al. (2018) Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol 596:827-855
Jhun, Bong Sook; O-Uchi, Jin; Adaniya, Stephanie M et al. (2018) Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology. Antioxidants (Basel) 7:
Allawzi, Ayed M; Vang, Alexander; Clements, Richard T et al. (2018) Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis. Am J Respir Cell Mol Biol 58:658-667
Disdier, Clémence; Zhang, Jiyong; Fukunaga, Yuki et al. (2018) Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats. Int J Dev Neurosci 65:54-60
Spasova, Mariya S; Chen, Xiaodi; Sadowska, Grazyna B et al. (2017) Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus. Dev Neurobiol 77:726-737
Bar, Daniel Z; Arlt, Martin F; Brazier, Joan F et al. (2017) A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome. J Med Genet 54:212-216
Liang, Olin D; So, Eui-Young; Egan, Pamela C et al. (2017) Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension. Cardiovasc Res 113:1560-1573

Showing the most recent 10 out of 17 publications