The scientific aims of our COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. Our research focus during Phase I and Phase II has been driven by recognition that the fundamental mechanisms that regulate embryonic development, cancer, and aging are overlapping. The success of our projects has been enhanced by the common view that looking through this prism of development provides unique experimental leverage and testable hypotheses for how regulatory pathways are governed later in life. The programmatic aims of the COBRE have been to create a Center for Perinatal Biology providing scientific and career mentoring to junior faculty within an environment fostering creativity and transdisciplinary collaboration. During Phase III of the COBRE for Perinatal Biology, our objectives will be: 1) continued support of COBRE-related activities; 2) transition the Center to sustainability; and 3) enhance perinatal and developmental research at Women & Infants Hospital. Resources for the Research Core programs will be used to upgrade existing instrumentation to enhance our research sophistication. The Pilot Grants Program associated with the Phase-III COBRE will be used to stimulate collaborative research efforts that will contribute to joint applications among the investigators and sustaining resources for the Core Facilities.
The Specific Aims we have identified to accomplish these goals are:
Specific Aim 1 : Provide Overall Leadership supporting the Administrative Core's ability to manage the operations and to transition the COBRE for Perinatal Biology into a sustainable Center for Perinatal Biology toward long-term sustainability.
Specific Aim 2 : Develop a sustainable, state-of-the-art Research Core that maximizes the use and impact of contemporary approaches, equipment, and technology for Perinatal Research.
Specific Aim 3 : Utilize Pilot Grants Program resources to catalyze multi-disciplinary research leading to additional extramural awards in Perinatal Research.

Public Health Relevance

Our research has been driven by recognition that the fundamental mechanisms that regulate embryonic development, cancer, and aging are similar. Insights discerned during developmental stages inform those other periods. The success of our projects has been enhanced by the common view that looking through the 'prism of development' provides not only those insights but, in some instances, experimental leverage and testable hypotheses for how regulatory pathways are governed later in life.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM114750-04
Application #
9485973
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Caldwell, Sheila
Project Start
2015-05-18
Project End
2020-04-30
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
Jhun, Bong Sook; O-Uchi, Jin; Adaniya, Stephanie M et al. (2018) Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol 596:827-855
Jhun, Bong Sook; O-Uchi, Jin; Adaniya, Stephanie M et al. (2018) Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology. Antioxidants (Basel) 7:
Allawzi, Ayed M; Vang, Alexander; Clements, Richard T et al. (2018) Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis. Am J Respir Cell Mol Biol 58:658-667
Disdier, Clémence; Zhang, Jiyong; Fukunaga, Yuki et al. (2018) Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats. Int J Dev Neurosci 65:54-60
Chen, Xiaodi; Patra, Aparna; Sadowska, Grazyna B et al. (2018) Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain. Dev Neurosci 40:234-245
Cheng, Shi-Bin; Davis, Sarah; Sharma, Surendra (2018) Maternal-fetal cross talk through cell-free fetal DNA, telomere shortening, microchimerism, and inflammation. Am J Reprod Immunol 79:e12851
Neale, Matthew N; Glass, Kyle A; Longley, Sarah J et al. (2018) Role of the inducible adhesin, CpAls7, in binding of Candida parapsilosis to extracellular matrix under fluid shear. Infect Immun :
Liang, Olin D; So, Eui-Young; Egan, Pamela C et al. (2017) Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension. Cardiovasc Res 113:1560-1573
Najrana, Tanbir; Ramos, Lauren M; Abu Eid, Rasha et al. (2017) Oligohydramnios compromises lung cells size and interferes with epithelial-endothelial development. Pediatr Pulmonol 52:746-756
Bliss, Joseph M; Wynn, James L (2017) Editorial: The Neonatal Immune System: A Unique Host-Microbial Interface. Front Pediatr 5:274

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