This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-07-012. The MRDDRC consists of the Administrative Core (Core A) with four subdivisions, and four research cores (Cores B, C, D, and E). Core A (Administrative), provides overall leadership, management, and organizational support to the Center, operates the educational component (lectures and seminars), links users to biostatistical services (a research subdivision), assists with preparation of IRB materials, monitors issues of human research protection, and develops participant registries. Core B (Genetics) provides centralized tissue culture, amino acid/organic acid analyses, standard and molecular cytogenetics, specialized molecular genetics (DNA and RNA analyses) microarrarys and bioinformatics. Core C (Neuroscience) provides synaptic neurochemistry (focusing on histology imaging and high performance liquid chromatography) and lipid biochemistry (lipid metabolism, fatty acid analysis, and mass spectrometry services). Core D (Neuroimaging) provides for acquisition and quantitative analysis of data derived from functional, volumetic, diffusion tensor, and spectroscopic MR imaging. Core E (Behavior Science) offers training of subjects for cooperation with research protocols, selection and administration of standardized tests (developmental, cognitive, and functional), direct observations of behavior, design of activation paradigms for fMRI, and motion analysis (e.g., quantitative computer-assisted methods of documenting gaits, reaching, and learning behaviors within the motor domain). The core units serve 156 projects representing current direct annual NIH support totaling over $104 million dollars. The program addresses 30 of the 31 priority areas set forth in the RFA-HD-07-012, featuring interdisciplinary collaboration and a central theme, brain mechanisms whereby genotypes result in specific cognitive and behavioral phenotypes of mental retardation or developmental disability.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
3P30HD024061-25S1
Application #
8743404
Study Section
Special Emphasis Panel (ZHD1-MRG-C (12))
Program Officer
Parisi, Melissa
Project Start
1997-08-01
Project End
2014-06-30
Budget Start
2013-09-28
Budget End
2014-06-30
Support Year
25
Fiscal Year
2013
Total Cost
$242,400
Indirect Cost
$92,400
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Jenkins, Edmund C; Ye, Lingling; Krinsky-McHale, Sharon J et al. (2016) Telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome. Am J Med Genet B Neuropsychiatr Genet 171B:169-74
Schneider, Heather E; Lam, Janet C; Mahone, E Mark (2016) [Formula: see text]Sleep disturbance and neuropsychological function in young children with ADHD. Child Neuropsychol 22:493-506
Diehl, Adam; Mu, Weiyi; Batista, Denise et al. (2015) An atypical 0.73 MB microduplication of 22q11.21 and a novel SALL4 missense mutation associated with thumb agenesis and radioulnar synostosis. Am J Med Genet A 167:1644-9
Walsh, D M; Doran, E; Silverman, W et al. (2015) Rapid assessment of cognitive function in down syndrome across intellectual level and dementia status. J Intellect Disabil Res 59:1071-9
Reinblatt, Shauna P; Mahone, E Mark; Tanofsky-Kraff, Marian et al. (2015) Pediatric loss of control eating syndrome: Association with attention-deficit/hyperactivity disorder and impulsivity. Int J Eat Disord 48:580-8
Lee, Ryan W Y; Jacobson, Lisa A; Pritchard, Alison E et al. (2015) Jitter Reduces Response-Time Variability in ADHD: An Ex-Gaussian Analysis. J Atten Disord 19:794-804
Porambo, Michael; Phillips, Andre W; Marx, Joel et al. (2015) Transplanted glial restricted precursor cells improve neurobehavioral and neuropathological outcomes in a mouse model of neonatal white matter injury despite limited cell survival. Glia 63:452-65
Benbadis, Selim R; Ewen, Joshua B; Schreiber, John M et al. (2015) Variations in EEG discharges predict ADHD severity within individual Smith-Lemli-Opitz patients. Neurology 84:436
Reinblatt, Shauna P; Leoutsakos, Jeannie-Marie S; Mahone, E Mark et al. (2015) Association between binge eating and attention-deficit/hyperactivity disorder in two pediatric community mental health clinics. Int J Eat Disord 48:505-11
Koriakin, Taylor A; Mahone, E Mark; Jacobson, Lisa A (2015) Sleep Difficulties are Associated with Parent Report of Sluggish Cognitive Tempo. J Dev Behav Pediatr 36:717-23

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