Core A The overall objective of the Administrative and Biostatistics Core (Core A) is to provide administrative support services to investigators at the DAB MRRC including: scientific and administrative leadership for the MRRC as a whole;management of the fiscal and personnel activities necessary to achieve the objectives of the MRRC and the research cores;an external Scientific Advisory Committee to provide scientific advice for the MRRC;development of Biostatistics support for MRDD surveillance studies within Alabama including the identification of familial clusters for further genetic study and providing biostatistical support to MRRC Core users;facilitation of center-wide collaborations designed to increase the identity of the MRRC; maintenance of an effective website to facilitate sharing of ideas and findings more generally with relevant groups of practitioners and service providers, advocates and consumers, policy- and decision-makers, and the general public;high quality, media support services to investigators primarily for presentation of findings at scientific meetings and in journals;support for pilot research and feasibility studies critical for determining the MRRC's future direction and for increasing competitiveness of investigators for outside funding; technical assistance and other support services to collaborative teams of MRRC investigators seeking funding for MRDD research and training, including assistance in planning and preparing grants;attraction of new investigators to the MRRC and to the field of mental retardation and neurodevelopmental disabilities, including joint recruitment with relevant departments;and data sharing and communications links to other MRRC's, other investigators at other institutions outside the MRRC network and with the NICHD community.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
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Special Emphasis Panel (ZHD1-MRG-C)
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University of Alabama Birmingham
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Butler, Anderson A; Webb, William M; Lubin, Farah D (2016) Regulatory RNAs and control of epigenetic mechanisms: expectations for cognition and cognitive dysfunction. Epigenomics 8:135-51
Heaven, Michael R; Flint, Daniel; Randall, Shan M et al. (2016) Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease. J Proteome Res 15:2265-82
Robel, Stefanie; Buckingham, Susan C; Boni, Jessica L et al. (2015) Reactive astrogliosis causes the development of spontaneous seizures. J Neurosci 35:3330-45
Tarquinio, Daniel C; Hou, Wei; Neul, Jeffrey L et al. (2015) Age of diagnosis in Rett syndrome: patterns of recognition among diagnosticians and risk factors for late diagnosis. Pediatr Neurol 52:585-91.e2
Tarquinio, Daniel C; Hou, Wei; Neul, Jeffrey L et al. (2015) The Changing Face of Survival in Rett Syndrome and MECP2-Related Disorders. Pediatr Neurol 53:402-11
Robert, Stephanie M; Buckingham, Susan C; Campbell, Susan L et al. (2015) SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma. Sci Transl Med 7:289ra86
Cuddapah, Vishnu Anand; Pillai, Rajesh B; Shekar, Kiran V et al. (2014) Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome. J Med Genet 51:152-8
Buckingham, Susan C; Ramos, Theresa N; Barnum, Scott R (2014) Complement C5-deficient mice are protected from seizures in experimental cerebral malaria. Epilepsia 55:e139-42
Xu, Xin; Kozikowski, Alan P; Pozzo-Miller, Lucas (2014) A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome. Front Cell Neurosci 8:68
Lucas, Elizabeth K; Dougherty, Sarah E; McMeekin, Laura J et al. (2014) PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons. J Neurosci 34:14375-87

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