A. Objective The IDDRC Neuroimaging Core provides support for all aspects of human neuroimaging research necessary for the IDDRC mission. The core supports a growing group of investigators that have unique experience in imaging normal brain development and children with a wide range of intellectual and developmental disabilities. We also place an emphasis on young investigator development. Advanced neuroimaging technology provides a critical means for evaluating the structural anatomy, biochemistry, and functional anatomical abnormalities that underlie developmental disabilities in addition to identifying disease/disorder biomarkers. Furthermore, imaging provides objective measures for examining the consequences of these disorders on brain structure and function, and providing a non-invasive means for exploring human neuroplasticity, adaptation in response to disease, and response to neuro-intervention. The Neuroimage Core: 1. Provides consultation in identifying efficient and effective imaging protocols to investigate experimental questions in specific clinical populations and during normal development 2. Provides consultation in processing and data analysis of structural and functional MRI scans in studies designed to detect alterations in brain structure, connectivity, or regional cortical activation 3. Provides access to and specific training in the use of the 3.0T MRI systems for structural, functional, and metabolic imaging 4. Supports investigators in developing and utilizing functional imaging tasks ("paradigms") focusing on visual, auditory, and sensorimotor processing, memory, language, executive function, and visuospatial skills, among others 5. Implements and supports techniques to desensitize anxious research subjects to the staff, settings, equipment and procedures associated with neuroimaging 6. Assists in selection, and implementation, and interpretation of statistical plan (with statistical core) 7. Performs imaging assessments of children, adolescents and adults 8. Assists in manuscript preparation for studies involving imaging 9. Assists in the monitoring of outcomes (efficacy, safety) in clinical trials utilizing imaging measures 10. Provides support and training for new investigators (and research assistants/personnel) entering the neuroimaging field.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZHD1)
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Children's Research Institute
United States
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Sokolowski, Katie; Tran, Tuyen; Esumi, Shigeyuki et al. (2016) Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei. Neural Dev 11:12
Glezer, Laurie S; Eden, Guinevere; Jiang, Xiong et al. (2016) Uncovering phonological and orthographic selectivity across the reading network using fMRI-RA. Neuroimage 138:248-56
Karpinski, Beverly A; A Bryan, Corey; Paronett, Elizabeth M et al. (2016) A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol 415:228-41
You, Wonsang; Evangelou, Iordanis E; Zun, Zungho et al. (2016) Robust preprocessing for stimulus-based functional MRI of the moving fetus. J Med Imaging (Bellingham) 3:026001
Tasker, Robert C; Goodkin, Howard P; Sánchez Fernández, Iván et al. (2016) Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med 17:968-975
Mukhamedova, Nigora; Brichacek, Beda; Darwish, Christina et al. (2016) Analysis of ABCA1 and Cholesterol Efflux in HIV-Infected Cells. Methods Mol Biol 1354:281-92
Sreetama, S C; Takano, T; Nedergaard, M et al. (2016) Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis. Cell Death Differ 23:596-607
Uittenbogaard, Martine; Chiaramello, Anne (2016) Novel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells. Histochem Cell Biol 145:275-86
Ratto, Allison B; Anthony, Bruno J; Kenworthy, Lauren et al. (2016) Are Non-intellectually Disabled Black Youth with ASD Less Impaired on Parent Report than Their White Peers? J Autism Dev Disord 46:773-81
Govindan, R B; Kota, Srinivas; Al-Shargabi, Tareq et al. (2016) Effect of electrocardiogram interference on cortico-cortical connectivity analysis and a possible solution. J Neurosci Methods 270:76-84

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