INTERNATIONAL HIV MEDICINE AND RESEARCH CORE The Comprehensive NeuroAIDS Center Core (CNACC)/International HIV Medicine and Research Core (IHMRC) will implement a subset of medical, research, and education objectives between the nongovernmental organization Freedom Foundation (FF) in Bangalore, India, Drexel University College of Medicine (DM), and Temple University (TM). The FF headquarters in collaboration with DM is located in Bangalore and is comprised of a (1) FF/DM Out-patient HIV/AIDS Care and Support Center caring for nearly 2,000 HIV-1-infected patients;(2) FF/DM In-patient HIV/AIDS Clinical Care Facility caring for approximately 100 HIV-1-infected patients at any given time, and (3) FF/DM HIV Clinical and Translational Research Center. In the past year, these efforts expanded to include the FF out-patient HIV/AIDS clinical care facility in Hyderabad, India which currently cares for an additional 1,000 HIV/AIDS patients. The CNACC/IHMRC will strive to facilitate the development and completion of international clinical/translational/basic research projects developed by NeuroAIDS investigators that focus on molecular mechanisms, diagnosis, treatment, and prevention of commonly encountered major and minor neurocognitive disorders associated with HIV-1 infection of the brain with particular attention focused on defining differences between HIV-1 subtype B and C infection.
The Specific Aims of the IHMRC will provide faculty/clinical fellows/students with an opportunity to participate in: (1) clinical research care of HIV-1 subtype C-infected research subjects at the FF in Bangalore, India;(2) generation, storage, and on-site use of HIV-1-infected patient samples for experiments performed in India;(3) generation, storage, and on-site use of PBMC genomic DNA, RNA, and protein samples from HIV-1-infected patients;(4) construction, update, and management of independent and integrated de-identified HIV-1 subtype C-infected patient electronic health record information and preparation of research progress reports, grant applications, and publications;(5) multi-site and on-site collaborative research projects at the FF/DM HIV Clinical and Translational Research Center;and (6) preparation, submission, and renewal of Institutional Review Board (IRB) protocols for Indian investigations.

Public Health Relevance

Subtype C viruses remain under-investigated with respect to patients suffering from neurologic complications. The IHMRC will develop and characterize a subtype C cohort in India to focus on defining the mechanisms of neurologic disease in subtype C-infected individuals and understand the differences between subtype B and C viral genotypes and phenotypes important in disease.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Temple University
United States
Zip Code
Dampier, Will; Antell, Gregory C; Aiamkitsumrit, Benjamas et al. (2016) Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status. J Neurovirol :
Datta, Prasun K; Kaminski, Rafal; Hu, Wenhui et al. (2016) HIV-1 Latency and Eradication: Past, Present and Future. Curr HIV Res 14:431-441
Sariyer, Rahsan; De-Simone, Francesca Isabella; Gordon, Jennifer et al. (2016) Immune suppression of JC virus gene expression is mediated by SRSF1. J Neurovirol :
Kaminski, Rafal; Chen, Yilan; Fischer, Tracy et al. (2016) Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Sci Rep 6:22555
Regan, Patrick M; Sariyer, Ilker K; Langford, T Dianne et al. (2016) Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X Signaling. J Cell Physiol 231:1542-53
Zhong, Lin; Li, Hao; Li, Zhiqiang et al. (2016) C7 genotype of the donor may predict early bacterial infection after liver transplantation. Sci Rep 6:24121
Strazza, Marianne; Pirrone, Vanessa; Wigdahl, Brian et al. (2016) Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier. Int J Mol Sci 17:
Kaminski, R; Bella, R; Yin, C et al. (2016) Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study. Gene Ther 23:690-5
Wollebo, Hassen S; Bellizzi, Anna; Cossari, Dominique H et al. (2016) The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. J Neurovirol 22:615-625
Feng, Dechun; Dai, Shen; Liu, Fengming et al. (2016) Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clin Invest 126:2321-33

Showing the most recent 10 out of 86 publications