Abstract

Core C ? Behavioral and In Vivo Neurophysiology Core (BINC) Summary The Behavioral and In Vivo Neurophysiology Core (BINC) will provide appropriate facilities and educational and consulting services that allow Rocky Mountain Neurological Disorders Center Core (RMNDC) investigators to perform behavioral and in vivo neurophysiological phenotyping of rodent models. Behavioral phenotyping, through structured established and novel tasks, is necessary for all aspects of basic and translational neuroscience research. Behavioral testing allows detailed characterization of motor, sensory, emotional, social and cognitive output of brain circuits that can be correlated to investigator initiated manipulations. Similarly, video monitoring coupled with electroencephalography (EEG) /local field potentials (LFP) characteristics can be used to determine disease status, to understand the mechanisms of co-morbidity that can occur following an injury and to track the evolution of disease pathology after an initial insult. The ability to link findings from the subcellular level (e.g. Core B) to the output of brain circuits (e.g. Core A) through behavioral and neurophysiological characterization is both exciting and highly relevant to the mission of NINDS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS048154-14
Application #
9606101
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2020-12-31
Support Year
14
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Bourke, Ashley M; Bowen, Aaron B; Kennedy, Matthew J (2018) New approaches for solving old problems in neuronal protein trafficking. Mol Cell Neurosci 91:48-66
Gould, Elizabeth A; Busquet, Nicolas; Shepherd, Douglas et al. (2018) Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife 7:
Purkey, Alicia M; Woolfrey, Kevin M; Crosby, Kevin C et al. (2018) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep 25:974-987.e4
Cook, Sarah G; Bourke, Ashley M; O'Leary, Heather et al. (2018) Analysis of the CaMKII? and ? splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep 8:5448
Tracy, Matthew E; Tesic, Vesna; Stamenic, Tamara Timic et al. (2018) CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology 135:343-354
Williams, Jason S; Hsu, Jessica Y; Rossi, Christy Cortez et al. (2018) Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Dev Biol :
Frank, Guido K W; DeGuzman, Marisa C; Shott, Megan E et al. (2018) Association of Brain Reward Learning Response With Harm Avoidance, Weight Gain, and Hypothalamic Effective Connectivity in Adolescent Anorexia Nervosa. JAMA Psychiatry 75:1071-1080
Peña, Brisa; Laughter, Melissa; Jett, Susan et al. (2018) Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci 18:e1800079
Olsavsky, Aviva K; Shott, Megan E; DeGuzman, Marisa C et al. (2018) Neural correlates of taste reward value across eating disorders. Psychiatry Res Neuroimaging :
Ramirez-Gordillo, Daniel; Ma, Ming; Restrepo, Diego (2018) Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation. Front Cell Neurosci 12:48

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