The Massachusetts Institute of Technology (MIT) Laser Biomedical Research Center (LBRC) requests NIH funding support for 26-30 years of operation. Under the leadership of its new Director, Dr. Peter So, LBRC will provide integrative photonic solutions to complex problems in biological research, pharmaceutical development, and medical diagnosis. Dr. So will be assisted by three Associated Directors: Drs. Ramachandra Dasari, Moungi Bawendi, and Andrie Tokmakoff. These senior investigators have a broad range of biophotonics expertise allowing LBRC to put forth three Technology Research and Development Projects proposing new biophotonic methods in the areas of (1) flurosecence instrumentation and probe, (2) phase-resolved spectroscopy and imaging, and (3) Raman and two-dimensional infrared spectroscopies. These TR&D projects are design to create new biophotonic tools for our collaborators to tackle important biomedical research problems in their respective fields. LBRC feature eight of these Driving Biomedical Projects covering the study of molecular and cell biology, neurobiology, cancer biology, diabetes diagnosis, and infectious disease treatment. In addition, LBRC also serve the biomedical community by disseminate matured technologies developed in the center. LBRC feature seven Collaborative Projects covering areas ranging from cancer, immunology, to tissue regeneration. Among these fifteen projects, half of these projects are led by investigators who have collaborated with LBRC in the past. The other half of these projects involves new researchers and new scientists. About 30 percent of these projects are conducted by teams led by clinicians. The rest of the projects are led by biologists or bioengineers. In additoin to research, collaboration and service, LBRC will also pursue a broad spectrum of activies in the dissemination of biophotonics technologies in the center and to train biomedical researcher in their uses. For the past 25 years, the success of LBRC has been built on research excellence and our ability to train stellar classes of biophotonics researchers. We look forward to carry on our mission and serve the biomedical community for the next five years.

Public Health Relevance

The LBRC develops integrative photonic solutions to complex problems in biological research, pharmaceutical development, and medical diagnosis problems including: cancer diagnosis and treatment;non-invasive glucose sensing;malaria detection;regenerative medicine;and gastric diseases. The success of LBRC has been built on its research excellence and the ability to train stellar biophotonics and biomedical spectroscopy researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015871-27
Application #
8469862
Study Section
Special Emphasis Panel (ZRG1-SBIB-S (40))
Program Officer
Conroy, Richard
Project Start
1997-06-01
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
27
Fiscal Year
2013
Total Cost
$1,208,343
Indirect Cost
$372,440
Name
Massachusetts Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Singh, Surya P; Mukherjee, Soumavo; Galindo, Luis H et al. (2018) Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing. Anal Bioanal Chem 410:6469-6475
Wadduwage, Dushan N; Kay, Jennifer; Singh, Vijay Raj et al. (2018) Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice. Sci Rep 8:12108
Zhang, Chi; Winnard Jr, Paul T; Dasari, Sidarth et al. (2018) Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations. Chem Sci 9:743-753
Rizwan, Asif; Paidi, Santosh Kumar; Zheng, Chao et al. (2018) Mapping the genetic basis of breast microcalcifications and their role in metastasis. Sci Rep 8:11067
Xue, Yi; So, Peter T C (2018) Three-dimensional super-resolution high-throughput imaging by structured illumination STED microscopy. Opt Express 26:20920-20928
Pandey, Rishikesh; Singh, Surya P; Zhang, Chi et al. (2018) Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples. J Biophotonics 11:e201700397
Carr, Jessica A; Franke, Daniel; Caram, Justin R et al. (2018) Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proc Natl Acad Sci U S A 115:4465-4470
Quinn, Steven D; Srinivasan, Shwetha; Gordon, Jesse B et al. (2018) Single-Molecule Fluorescence Detection of the Epidermal Growth Factor Receptor in Membrane Discs. Biochemistry :
Jin, Di; Zhou, Renjie; Yaqoob, Zahid et al. (2018) Dynamic spatial filtering using a digital micromirror device for high-speed optical diffraction tomography. Opt Express 26:428-437
Yannas, Ioannis V; Tzeranis, Dimitrios S; So, Peter T C (2018) Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales. Curr Opin Biomed Eng 6:1-7

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