This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Titin is a mechanical protein ( that protects muscle from overstretching, which can occur following a powerful muscle contraction. Defects in the titin gene have been correlated to muscular distrophy. Titin produces a restoring force when a muscle fiber is extended beyond its normal length. Much of what is understood about titin today arose from single-molecule experiments [1?7] and computer simulations [8?13] which have shed light on how the structure of titin resist mechanical stretching forces.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZRG1-BCMB-E (40))
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University of Illinois Urbana-Champaign
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Poudel, Kumud R; Dong, Yongming; Yu, Hang et al. (2016) A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes. Mol Biol Cell 27:2119-32
Belkin, Maxim; Chao, Shu-Han; Jonsson, Magnus P et al. (2015) Plasmonic Nanopores for Trapping, Controlling Displacement, and Sequencing of DNA. ACS Nano 9:10598-611
Vermaas, Josh V; Taguchi, Alexander T; Dikanov, Sergei A et al. (2015) Redox potential tuning through differential quinone binding in the photosynthetic reaction center of Rhodobacter sphaeroides. Biochemistry 54:2104-16
Shen, Rong; Han, Wei; Fiorin, Giacomo et al. (2015) Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments. PLoS Comput Biol 11:e1004368
Han, Wei; Schulten, Klaus (2014) Fibril elongation by Aβ(17-42): kinetic network analysis of hybrid-resolution molecular dynamics simulations. J Am Chem Soc 136:12450-60
Hallock, Michael J; Stone, John E; Roberts, Elijah et al. (2014) Simulation of reaction diffusion processes over biologically relevant size and time scales using multi-GPU workstations. Parallel Comput 40:86-99
Vermaas, Josh V; Tajkhorshid, Emad (2014) A microscopic view of phospholipid insertion into biological membranes. J Phys Chem B 118:1754-64
Han, Wei; Cheng, Ricky C; Maduke, Merritt C et al. (2014) Water access points and hydration pathways in CLC H+/Cl- transporters. Proc Natl Acad Sci U S A 111:1819-24
Kutálková, Eva; Hrnčiřík, Josef; Ingr, Marek (2014) Pressure induced structural changes and dimer destabilization of HIV-1 protease studied by molecular dynamics simulations. Phys Chem Chem Phys 16:25906-15
Shim, Jiwook; Humphreys, Gwendolyn I; Venkatesan, Bala Murali et al. (2013) Detection and quantification of methylation in DNA using solid-state nanopores. Sci Rep 3:1389

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