The Training Core will interact with all aspects of the Center by virtue of its goal, which is to facilitate the teaching of creative science thinking, especially by creating an atmosphere that nurtures students'creative insights (DeHaan, 2011). Creative insight stems from abstract thinking plus two types of mental operations: 1) associative (divergent) thinking involving thoughts that are defocused, intuitive and, importantly, receptive to a range of associations;and 2) analytical (convergent) thinking, i.e., the capacity to analyze, synthesize and focus (DeHaan, 2011). Furthermore, we are acutely aware of the need to train scientists who can work across traditional disciplinary boundaries. Thus, we are striving for an integrated model for science education (Lorsch and Nichols, 2011) that provides interdisciplinary training that enables trainees to speak the many scientific languages spoken across the range of the research undertaken by the SRP Center investigative team. Our hypothesis is that cross-training of students participating in the MSU P42 Center Grant in disciplines not traditionally linked with the university structure will be achieved through a multifaceted training approach involving laboratory based research combined with formal and informal instruction.
The Specific Aims are: SAI) Provide interdisciplinary training to predoctoral and postdoctoral students through research collaborations across biomedical and non-biomedical research projects and cores within the Michigan State University Superfund Research Program (MSU SRP) Center;SA2) Provide interdisciplinary training to predoctoral and postdoctoral students through a monthly journal club;and SA3) Provide interdisciplinary training to predoctoral and postdoctoral students through formal instruction (e.g.. Computational Biology and Dose Response courses, Distinguished Scholars in Toxicology Lecture Series as well as other seminars on the MSU campus, travel to provide special educational opportunities and elective courses designed to facilitate designed to facilitate movement towards """"""""Convergence"""""""" the third revolution in the biological sciences, i.e., convergence ofthe life sciences, engineering and the physical sciences Sharp et al., 2011). The implementation of these specific aims will, in a synergistic fashion, facilitate the training of graduate students and postdoctoral fellows who will be afforded a forward thinking interdisciplinary focus and, therefore, be prepared to tackle current and future environmentally-related human health issues.
The Training Core has developed an innovative combination of activities involving fostering research that crosses/bridges biomedical, environmental, and engineering research, an interdisciplinary Journal Club and interdisciplinary training through formal instruction. These is designed to facilitate integration of the SRP investigative team's research efforts through a coordinated multifaceted training program which emphasizes cross disciplinary approaches to the research efforts at hand.
|Nault, Rance; Doskey, Claire M; Fader, Kelly A et al. (2018) Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol 94:876-884|
|Dornbos, Peter; LaPres, John J (2018) Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8|
|Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Interfacial Structure and Interaction of Kaolinite Intercalated with N-methylformamide Insight from Molecular Dynamics Modeling. Appl Clay Sci 158:204-210|
|Fader, Kelly A; Nault, Rance; Raehtz, Sandi et al. (2018) 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98|
|Zhang, Shuai; Liu, Qinfu; Cheng, Hongfei et al. (2018) Mechanism Responsible for Intercalation of Dimethyl Sulfoxide in Kaolinite: Molecular Dynamics Simulations. Appl Clay Sci 151:46-53|
|Zhang, Qiang; Li, Jin; Middleton, Alistair et al. (2018) Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. Front Public Health 6:261|
|Fader, K A; Nault, R; Kirby, M P et al. (2018) Corrigendum to ""Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERB?/? activation in aryl hydrocarbon receptor-elicited hepatotoxicity"" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17]. Toxicol Appl Pharmacol 344:74|
|Konganti, Kranti; Ehrlich, Andre; Rusyn, Ivan et al. (2018) gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3 (Bethesda) 8:2559-2562|
|Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Molecular Dynamics Simulation of Basal Spacing, Energetics, and Structure Evolution of a Kaolinite-Formamide Intercalation Complex and Their Interfacial Interaction. J Phys Chem C Nanomater Interfaces 122:3341-3349|
|Williams, M R; Stedtfeld, R D; Waseem, H et al. (2017) Implications of direct amplification for measuring antimicrobial resistance using point-of-care devices. Anal Methods 9:1229-1241|
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