The burgeoning prevalence and devastating public health implications of Alzheimer's disease (AD) demand a concomitant increase in AD-related research and education. The primary objectives of the Education and Information Core are to facilitate the recruitment and retention of subjects into research protocols and clinical trials, emphasizing ethnic minority and rural populations;and to develop and maintain innovative programs that provide professional staff with clinical and research skills related to AD and other dementias. This proposal outlines a detailed set of integrated outreach and educational activities designed to meet our overarching objectives while responding to the education and outreach needs of the local communities surrounding the University of Pittsburgh ADRC. The activities of this Core will be systematically evaluated to measure their effects on immediate outcomes specific to each activity, as well as their contribution to the Core's overarching objectives. Key features of this Core include a commitment to ongoing needs assessment within our community of interest, and a quality improvement approach to continually increasing the rigor of our evaluation processes.
The successful execution of clinical research on Alzeimer's disease hinges upon the availability and willingness of human subjects to participate in research protocols and clinical trials. The bulk of activities associated with this Core are designed to engage large and representative pools of older adults in clinical research on AD, thereby advancing the overall mission of this ADRC.
|Flatt, Jason D; Liptak, Amy; Oakley, Mary Ann et al. (2015) Subjective experiences of an art museum engagement activity for persons with early-stage Alzheimer's disease and their family caregivers. Am J Alzheimers Dis Other Demen 30:380-9|
|Wang, Xingbin; Lopez, Oscar L; Sweet, Robert A et al. (2015) Genetic determinants of disease progression in Alzheimer's disease. J Alzheimers Dis 43:649-55|
|Klunk, William E; Koeppe, Robert A; Price, Julie C et al. (2015) The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement 11:1-15.e1-4|
|Hu, Wei; MacDonald, Matthew L; Elswick, Daniel E et al. (2015) The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies. Ann N Y Acad Sci 1338:38-57|
|Riverol, Mario; Becker, James T; López, Oscar L et al. (2015) Relationship between Systemic and Cerebral Vascular Disease and Brain Structure Integrity in Normal Elderly Individuals. J Alzheimers Dis 44:319-28|
|Chaudhry, Mamoonah; Wang, Xingbin; Bamne, Mikhil N et al. (2015) Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease. J Alzheimers Dis 44:989-94|
|Sanders, Laurie H; McCoy, Jennifer; Hu, Xiaoping et al. (2014) Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiol Dis 70:214-23|
|Raji, Cyrus A; Erickson, Kirk I; Lopez, Oscar L et al. (2014) Regular fish consumption and age-related brain gray matter loss. Am J Prev Med 47:444-51|
|Hong, Young T; Veenith, Tonny; Dewar, Deborah et al. (2014) Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 71:23-31|
|Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606|
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