The Mayo Alzheimer's Disease Research Center (ADRC) is located in Rochester, MN and Jacksonville, FL and will pursue two themes: 1) The recruitment and characterization of subjects in the early stages of the cognitive spectrum from aging to Alzheimer's disease (AD) particularly focusing on mild cognitive impairment (MCI), and 2) the study of non-AD dementias including frontotemporal lobar degeneration and dementia with Lewy bodies. The ADRC will consist of 5 cores: Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core and Education and Information Transfer Core. The cores will interact with each other and will support three proposed research projects: 1) Identifying Multi-modality Imaging Correlates of Dementia with Lewy Bodies and AD, 2) The PGRN/TDP-43 Axis in Alzheimer's Disease and Neurodegeneration, and 3) Identification of AD Risk Variants by Genome Wide Association of Gene Expression. The cores will be led by established investigators in the field and the three projects will be directed by younger but experienced and productive investigators in their respective areas of research who have not been project leaders in the past. All three were trained in the ADRC environment by prominent investigators in dementia research and they will continue to explore well-established research themes. The ADRC staff has produced 340 publications, 70 chapters and 276 abstracts in the current grant cycle and will continue this productivity in the proposed grant cycle. The Center will continue its work on the UDS and contribute to the NACC database. Research on MCI, neuroimaging and clinical-pathological correlations will continue through the intense collaboration among the cores and projects. The ADRC will also continue to be a training platform for young investigators.
The Mayo Alzheimer's Disease Research Center will be addressing many of the central issues in dementia research through its focus on early detection of disease, exploration of non-AD dementias and the cognitive characterization of African-American subjects. These themes are vital and aimed at ultimately developing therapies for dementing disorders with the ultimate goal being prevention of the diseases. The structure of the Center allows the interaction of numerous scientists to pursue cutting edge research in dementia.
|Kertesz, A; Finger, E; Murrell, J et al. (2015) Progressive supranuclear palsy in a family with TDP-43 pathology. Neurocase 21:178-84|
|Zhang, Bing; Ferman, Tanis J; Boeve, Bradley F et al. (2015) MRS in mild cognitive impairment: early differentiation of dementia with Lewy bodies and Alzheimer's disease. J Neuroimaging 25:269-74|
|Nedelska, Zuzana; Ferman, Tanis J; Boeve, Bradley F et al. (2015) Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging 36:452-61|
|Steffen, Teresa M; Boeve, Bradley F; Petersen, Cheryl M et al. (2014) Long-term exercise training for an individual with mixed corticobasal degeneration and progressive supranuclear palsy features: 10-year case report follow-up. Phys Ther 94:289-96|
|Shinohara, Mitsuru; Fujioka, Shinsuke; Murray, Melissa E et al. (2014) Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain 137:1533-49|
|van Blitterswijk, Marka; Mullen, Bianca; Wojtas, Aleksandra et al. (2014) Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Mol Neurodegener 9:38|
|Cannon, Ashley; Bieniek, Kevin F; Lin, Wen-Lang et al. (2014) Concurrent variably protease-sensitive prionopathy and amyotrophic lateral sclerosis. Acta Neuropathol 128:313-5|
|Mielke, Michelle M; Weigand, Stephen D; Wiste, Heather J et al. (2014) Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging. Alzheimers Dement 10:779-89|
|Graff-Radford, Jonathan; Murray, Melissa E; Lowe, Val J et al. (2014) Dementia with Lewy bodies: basis of cingulate island sign. Neurology 83:801-9|
|Winslow, Ashley R; Moussaud, Simon; Zhu, Liya et al. (2014) Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. Brain 137:1958-70|
Showing the most recent 10 out of 556 publications