Few funding opportunities exist nationwide for pilot projects that are focused on bladder cancer (BC). Furthermore, as the only program of its kind in the country, the MD Anderson BC SPORE must reach out directly to other translational scientists who are or may become interested in BC research by fostering interinstitutional collaboration. To address these important needs, the SPORE Developmental Research Program has evolved from a structure that largely supported projects based at MD Anderson to one that seeks to establish collaborations with groups at other institutions and establish flexible and nimble processes for identifying and rapidly funding them. To this end, we propose the following Specific Aims in this renewal application: 1.To identify potentially high impact emerging translational research projects focused on urothelial cancer,preferably at other institutions; 2. To provide seed funding for these projects for 1-2 years; 3. To incorporate the most successful as full projects within the SPORE.

Public Health Relevance

Bladder cancer is very common and costly, yet research support for BC has lagged behind that provided for other malignancies. The primary goal of the MD Anderson BC SPORE DRP is to serve as a source of seed funding for meritorious BC projects nationwide. Secondary objectives include establishing functional collaborative networks and recruiting talented new investigators to the field.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA091846-13
Application #
8745037
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
City
Houston
State
TX
Country
United States
Zip Code
77030
Lin, Moubin; Zhang, Liren; Hildebrandt, Michelle A T et al. (2017) Common, germline genetic variations in the novel tumor suppressor BAP1 and risk of developing different types of cancer. Oncotarget 8:74936-74946
Shore, Neal D; Boorjian, Stephen A; Canter, Daniel J et al. (2017) Intravesical rAd-IFN?/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study. J Clin Oncol 35:3410-3416
Wang, Gang; Huang, He; Kamat, Ashish M et al. (2017) High-grade neuroendocrine carcinoma of the urachus-report of 3 cases. Hum Pathol 67:126-133
Robertson, A Gordon; Kim, Jaegil; Al-Ahmadie, Hikmat et al. (2017) Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell 171:540-556.e25
von Rundstedt, Friedrich-Carl; Mata, Douglas A; Kryvenko, Oleksandr N et al. (2017) Utility of Clinical Risk Stratification in the Selection of Muscle-Invasive Bladder Cancer Patients for Neoadjuvant Chemotherapy: A Retrospective Cohort Study. Bladder Cancer 3:35-44
Williams, Stephen B; Kamat, Ashish M; Mmeje, Chinedu et al. (2017) Genetic variants in the inflammation pathway as predictors of recurrence and progression in non-muscle invasive bladder cancer treated with Bacillus Calmette-Guérin. Oncotarget 8:88782-88791
Mobley, Aaron; Zhang, Shizhen; Bondaruk, Jolanta et al. (2017) Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior. Sci Rep 7:40714
Roth, Beat; Jayaratna, Isuru; Sundi, Debasish et al. (2017) Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis. Oncotarget 8:34205-34222
Metcalfe, Michael J; Ferguson, James E; Li, Roger et al. (2017) Impact of High-risk Features and Effect of Neoadjuvant Chemotherapy in Urothelial Cancer Patients with Invasion into the Lamina Propria on Transurethral Resection in the Absence of Deep Muscle Invasion. Eur Urol Focus :
Choi, Woonyoung; Ochoa, Andrea; McConkey, David J et al. (2017) Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset. Eur Urol 72:354-365

Showing the most recent 10 out of 237 publications