The goal of the Career Development Award Program (CDAP) of the Yale SPORE in Skin Cancer is to enhance our capacity to develop a new cadre of investigative cutaneous oncologists and scientists committed to multidisciplinary studies investigating the relevance of biological discoveries in human skin cancer risk, prevention, diagnosis, prognosis or treatment, as well as to enhance and focus the careers of individuals who have already shown interest and promise in this field. Requested funding for this component of the SPORE includes $70,000 per year with $50,000 in """"""""matching"""""""" funds from the Yale Cancer Center, to be used for the support of two faculty-level Career Development Awards per year. Funding is for one year, but may be renewed for a second year. Potential candidates for these awards include both promising junior faculty (either already holding appointments at Yale or outside candidates/new recruits for such Yale appointments), but also established Investigators, either currently at Yale or in the process of being recruited to Yale, whose previous research focus has been in other arenas, but who wish to re-orient a significant portion of their research on translational research in cutaneous oncology. All junior faculty awardees are paired with an established investigator in translational cutaneous/ oncology who also has a documented record of successful mentoring. During its initial five-year funding cycle, YSPORE CDAP funds were used to support the career development of 6 different investigators: four investigators (including one woman and one Hispanic) received support for two years each, while two others will have received support for one year each. Individuals supported to date have had diverse backgrounds and previous experience;2 PhDs, 2 MDs, and 2 MD/PhDs, with experience ranging from an established investigator in melanoma research newly recruited to Yale, to an established basic science investigator refocusing on translational investigation in cutaneous T cell lymphoma, to junior faculty just embarking on investigative careers in biostatistics, melanoma and squamous cell carcinoma. A similarly diverse group of outstanding potential future CDAP awardees have been identified for the next funding cycle.

Public Health Relevance

The Yale SPORE in Skin Cancer's Career Development Award Program has been designed to foster the development of the next generation of physician-scientists in the arena of human cutaneous malignancies. There has been a documented decrease over the past 20+ years in the numbers of individuals choosing such careers, and this program is aimed at helping to correct this problem.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA121974-08
Application #
8719050
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Ferrucci, Leah M; Cartmel, Brenda; Clare, Rachel A et al. (2018) Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. J Am Acad Dermatol 79:149-152
Arbesman, Joshua; Ravichandran, Sairekha; Funchain, Pauline et al. (2018) Melanoma cases demonstrate increased carrier frequency of phenylketonuria/hyperphenylalanemia mutations. Pigment Cell Melanoma Res 31:529-533
Perry, Curtis J; Muñoz-Rojas, Andrés R; Meeth, Katrina M et al. (2018) Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med 215:877-893
Liu, Xiaoni; Zhang, Shang-Min; McGeary, Meaghan K et al. (2018) KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations. Mol Cancer Ther :
Sulkowski, Parker L; Scanlon, Susan E; Oeck, Sebastian et al. (2018) PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF. Mol Cancer Res 16:1241-1254
Chen, Ling; Azuma, Takeshi; Yu, Weiwei et al. (2018) B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proc Natl Acad Sci U S A 115:3126-3131
Krauthammer, Michael (2018) Unraveling the etiology of primary malignant melanoma of the esophagus. J Thorac Dis 10:S1074-S1075
Das, Rituparna; Bar, Noffar; Ferreira, Michelle et al. (2018) Early B cell changes predict autoimmunity following combination immune checkpoint blockade. J Clin Invest 128:715-720
Miller, Chad J; Muftuoglu, Yagmur; Turk, Benjamin E (2017) A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases. Biochem Pharmacol 142:39-45
Kluger, Harriet M; Zito, Christopher R; Turcu, Gabriela et al. (2017) PD-L1 Studies Across Tumor Types, Its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors. Clin Cancer Res 23:4270-4279

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