In response to RFA-DK-11-009, our overall goal is to create a Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PGEN), to support basic, translational, and clinical research on critical pediatric kidney diseases that have major unmet needs. The overarching theme is to conduct innovative and high-impact bench-to-bedside studies on three critical but underserved pediatric kidney diseases. Our three areas of focus include acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis, already developed as areas of multidisciplinary expertise at our institution. The urgent need will be addressed by three individual research projects as well as by the three Biomedical Cores, all proposed by outstanding funded investigators with a track record of successful multidisciplinary collaborative efforts in the focu areas. The two novel exploratory pilot studies proposed by exceptional and promising young investigators will form the basis for their future investigator-initiated applications to study acue kidney injury.
The specific aims i nclude: (1) to attract outstanding scientific expertise into the study of critical but underserved pediatric kidney diseases;(2) to foster multidisciplinary approaches to the study of critical but underserved pediatric kidney diseases within our focus areas at the basic, translational, and clinical levels;(3) To provide high-resource Gene Expression, Proteomics, and Biomarker Cores to support the study of pediatric kidney diseases locally, regionally, and nationally;and (4) to support novel exploratory pilot studies that will form the basis for future investigator-initiated applications t study critical but underserved pediatric kidney diseases. Evidence for strong support from institutional leadership is provided. Added strengths include the CCHMC Pediatric Nephrology Division, with a proven track record of excellence and collaboration in the study of the three focus areas. Active support and collaboration from the institutional CTSA and from a large number of divisions that are involved in multidisciplinary collaborative efforts in the three focus areas of study provide the extended resources for success. The proposal also comes with active support and collaboration from our NIH funded T32 Fellowship Training Program.

Public Health Relevance

Pediatric kidney diseases due to acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis contribute to an enormous major impact on the U.S. public health and a major financial burden. The Pediatric Center of Excellence in Nephrology at CCHMC will bring together experts from multiple facets of science and medicine to focus their energies on these three disease states to change their dismal outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
1P50DK096418-01
Application #
8370707
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M3))
Program Officer
Moxey-Mims, Marva M
Project Start
2012-09-21
Project End
2017-08-31
Budget Start
2012-09-21
Budget End
2013-08-31
Support Year
1
Fiscal Year
2012
Total Cost
$878,253
Indirect Cost
$279,766
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Hornik, Christoph P; Krawczeski, Catherine D; Zappitelli, Michael et al. (2014) Serum brain natriuretic peptide and risk of acute kidney injury after cardiac operations in children. Ann Thorac Surg 97:2142-7
Haase-Fielitz, Anja; Haase, Michael; Devarajan, Prasad (2014) Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann Clin Biochem 51:335-51
Wang, Zhu; Ma, Shuangge; Zappitelli, Michael et al. (2014) Penalized count data regression with application to hospital stay after pediatric cardiac surgery. Stat Methods Med Res :
Jotwani, Vasantha; Scherzer, Rebecca; Abraham, Alison et al. (2014) Does HIV infection promote early kidney injury in women? Antivir Ther 19:79-87
Lennon, Michael; Devarajan, Prasad (2014) In memoriam of Clark Darwin West, MD July 4, 1918-January 11, 2014. Pediatr Nephrol 29:1293-4
Devarajan, Prasad (2014) NGAL for the detection of acute kidney injury in the emergency room. Biomark Med 8:217-9
Riley, Alyssa A; Jefferies, John L; Nelson, David P et al. (2014) Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery. Int J Artif Organs 37:39-47
Peralta, Ca; Scherzer, R; Grunfeld, C et al. (2014) Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS). HIV Med 15:291-300
Devarajan, Prasad (2013) Pediatric Acute Kidney Injury: Different From Acute Renal Failure But How And Why. Curr Pediatr Rep 1:34-40
Bagshaw, Sean M; Bennett, Michael; Devarajan, Prasad et al. (2013) Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study. J Crit Care 28:371-8

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