Project F: Genetics of mRNA processing;Joel H. Graber (Jackson) A complete model of gene regulation requires understanding control at all stages of expression from DNA through mRNA to final protein product. Response to environmental changes, such as diet, involves changes in expression at multiple stages of activation. Genetic bases for differences in post-transcriptional processing, such as alternative splicing and alternative polyadenylation, remain poorly understood. Genetically defined strains of mice, such as the DO and RIX, provide a powerful means of investigating genetic differences in gene expression and regulation in response to controlled changes in environment. Working in collaboration with projects C, D, and E we will investigate genetic differences in mRNA processing in response to dietary variation between normal chow, high vitamin D content, and high fat content.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076468-08
Application #
8531968
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$51,751
Indirect Cost
$22,805
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
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