THEME E: OPTICAL BIOLOGY: TOOLS FOR SPATIOTEMPORAL CORRRELATION AND NANOIMAGING (Enrico Gratton, Theme Leader) During the next funding period. Theme E will continue to contribute to education (through detailed workshops and training modules in graduate boot camps and the national short course), and to the integration of optical methods into the research of Themes A-C. For the latter, we will continue to maintain a facility in which we provide free access to advanced microscopy, build new capacity on an Olympus FV1000 microscope, and make available the new SPIM microscope we recently developed.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-08
Application #
8731909
Study Section
Special Emphasis Panel (ZGM1-CBCB-3)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
8
Fiscal Year
2014
Total Cost
$219,698
Indirect Cost
$77,498
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Lee, Mary; Chen, George T; Puttock, Eric et al. (2017) Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol 13:912
Bhattacharjee, Arunima; Datta, Rupsa; Gratton, Enrico et al. (2017) Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy. Sci Rep 7:3743
Digiacomo, L; Cardarelli, F; Pozzi, D et al. (2017) An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles. Nanoscale 9:17254-17262
Li, Chung-Jung; Hong, Tian; Tung, Ying-Tsen et al. (2017) MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord. Nat Commun 8:14685
Wan, Frederic Y M; Enciso, Germán A (2017) Optimal Proliferation and Differentiation of Chlamydia Trachomatis. Stud Appl Math 139:129-178
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Bardwell, A Jane; Lagunes, Leonila; Zebarjedi, Ronak et al. (2017) The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2. J Biol Chem 292:8750-8761
Bohórquez-Hernández, A; Gratton, Enrico; Pacheco, Jonathan et al. (2017) Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains. Biochim Biophys Acta 1862:1481-1490
Malacrida, Leonel; Jameson, David M; Gratton, Enrico (2017) A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes. Sci Rep 7:9215
Liu, Kai; Marple, Gary R; Allard, Jun et al. (2017) Dynamics of a multicomponent vesicle in shear flow. Soft Matter 13:3521-3531

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