Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG015474-01S1
Application #
2875739
Study Section
Immunobiology Study Section (IMB)
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
1998-09-30
Budget End
1999-03-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Wilson, Emily L; King, Anne M; Sherwood, Erin M et al. (2005) Pre-B cell loss in senescence coincides with preferential development of immature B cells characterized by partial activation and altered Vh repertoire. Exp Gerontol 40:67-79
Riley, Richard L; Blomberg, Bonnie B; Frasca, Daniela (2005) B cells, E2A, and aging. Immunol Rev 205:30-47
Frasca, Daniela; Nguyen, Diep; Riley, Richard L et al. (2004) Effects of aging on DNA-binding activity of the E47 transcription factor in splenic B cells. Mech Ageing Dev 125:111-2
Frasca, Daniela; Van der Put, Elaine; Riley, Richard L et al. (2004) Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J Immunol 172:2155-62
Van der Put, Elaine; Frasca, Daniela; King, Anne M et al. (2004) Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover. J Immunol 173:818-27
Frasca, Daniela; Van Der Put, Elaine; Riley, Richard L et al. (2004) Age-related differences in the E2A-encoded transcription factor E47 in bone marrow-derived B cell precursors and in splenic B cells. Exp Gerontol 39:481-9
Wilson, Emily L; Sherwood, Erin M; King, Anne M et al. (2003) A phenotypically distinct subset of immature B cells exhibits partial activation, increased survival, and preferential expression of VhS107. Eur J Immunol 33:3398-408
Frasca, Daniela; Nguyen, Diep; Van der Put, Elaine et al. (2003) The age-related decrease in E47 DNA-binding does not depend on increased Id inhibitory proteins in bone marrow-derived B cell precursors. Front Biosci 8:a110-6
Frasca, Daniela; Nguyen, Diep; Riley, Richard L et al. (2003) Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J Immunol 170:719-26
Frasca, Daniela; Nguyen, Diep; Riley, Richard L et al. (2003) Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells. Mech Ageing Dev 124:361-9

Showing the most recent 10 out of 16 publications