The overarching objective of the University Of Colorado Anschutz Medical Campus Specialized Center Of Research on Sex Differences (UCAMC SCOR) is to develop an interdisciplinary and translational research program to advance the understanding of the Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function. There is compelling evidence from studies of laboratory animals that gonadectomy causes a dramatic decrease of 30-80% in spontaneous physical activity in males and females. Even more intriguing is the observation that this results in excess weight gain, a marked increase in visceral fat, and metabolic dysfunction in female animals but not males. If such findings are relevant to humans, the age related decline in gonadal function may be an important independent determinant of disease risk. Moreover, this would be expected to have a greater adverse effect on the health of women than men, because the loss of gonadal function occurs at an earlier age in women. There will be three SCOR Research Projects to advance novel research in this area: 1) Project I (clinical): Bioenergetic and Metabolic Consequences of the Loss of Ovarian Function in Women (PI: W Kohrt);2) Project II (preclinical): Effects of Pre-existing Obesity on Consequences of the Loss of Ovarian Function (PI: P MacLean);and 3) Project III (basic): Sex Hormones Differentially Regulate Production of Distinct Adipocyte Populations (PI: D Klemm). The Administrative Core will contribute to the success of the SCOR by: 1) providing scientific leadership for a focused translational and transdisciplinary research program on the consequences of the loss of gonadal function;2) monitoring the productivity of SCOR Research Projects;3) expanding the scope of the SCOR through an Ancillary Projects program;4) expanding the cadre of investigators conducting research on the gonadal regulation of energy balance and metabolism through the Ancillary Projects program;5) integrating activities of the SCOR with closely partnered programs at UCAMC, including the Center on Aging, the BIRCWH, the Center for Women's Health Research, the Nutrition and Obesity Research Center, the Women's Reproductive Health Research Career Development program, and the Colorado Clinical and Translational Science Institute;6) providing biostatistical and data management support for the SCOR research projects;and 7) providing administrative support for financial oversight, regulatory oversight, and scheduling and general management of SCOR activities.

Public Health Relevance

The SCOR is closely aligned with the 2 required overarching themes: 1) all 3 projects address sex/gender determinants because they investigate biological effects of the loss of gonadal function that impact heath;and 2) the SCOR is interdisciplinary, as evidenced by the focus on the regulation of the lineage of adipocytes in mice (Project III), to the impact of local estradiol production on fat and muscle metabolism in rats (Project II), to the effect of the loss of gonadal function on physical activity and energy balance in women (Project I).

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1-EMNR-Q (50))
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Eisenberg, Esther
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University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
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Barbour, L A; Hernandez, T L; Reynolds, R M et al. (2016) Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes 11:264-71
Hernandez, Teri L; Van Pelt, Rachael E; Anderson, Molly A et al. (2016) Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care 39:39-42
Giles, Erin D; Steig, Amy J; Jackman, Matthew R et al. (2016) Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol 7:32
Rudolph, Michael C; Young, Bridget E; Jackson, Kristina Harris et al. (2016) Human Milk Fatty Acid Composition: Comparison of Novel Dried Milk Spot Versus Standard Liquid Extraction Methods. J Mammary Gland Biol Neoplasia 21:131-138
Melanson, Edward L; Gavin, Kathleen M; Shea, Karen L et al. (2015) Regulation of energy expenditure by estradiol in premenopausal women. J Appl Physiol (1985) 119:975-81
Pereira, R I; Casey, B A; Swibas, T A et al. (2015) Timing of Estradiol Treatment After Menopause May Determine Benefit or Harm to Insulin Action. J Clin Endocrinol Metab 100:4456-62
Van Pelt, Rachael E; Gavin, Kathleen M; Kohrt, Wendy M (2015) Regulation of Body Composition and Bioenergetics by Estrogens. Endocrinol Metab Clin North Am 44:663-76
Hernandez, Teri L; Bessesen, Daniel H; Cox-York, Kimberly A et al. (2015) Femoral lipectomy increases postprandial lipemia in women. Am J Physiol Endocrinol Metab 309:E63-71
Shea, Karen L; Gavin, Kathleen M; Melanson, Edward L et al. (2015) Body composition and bone mineral density after ovarian hormone suppression with or without estradiol treatment. Menopause 22:1045-52
Bessesen, Daniel H; Cox-York, Kimberly A; Hernandez, Teri Lynn et al. (2015) Postprandial triglycerides and adipose tissue storage of dietary fatty acids: impact of menopause and estradiol. Obesity (Silver Spring) 23:145-53

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