Sensory processing deficits are a key component of schizophrenia. This project will analyze mechanisms underlying sensory processing dysfunction using a multimodal imaging approach incorporating both neurophysiological and MRl-based assessments. Neurophysiological studies will evaluate role of neuronal synchrony and oscillatory hierarchy impairments in etiology of neurocognitive dysfunction. In particular, it will test the hypothesis that impairments in non-linear stimulus amplification and in oscillatory entrainment may prevent response optimization in patients relative to controls. Four experiments are planned. The first experiment will analyze the role of oscillatory entrainment in the genesis of previously documented sensory processing deficits and object-attention dysfunction. For this experiment, hierarchical oscillatory analyses will be conducted using mathematical approaches and stimulation paradigms developed from Projects 2 and 3, respectively. The second experiment will analyze the role of spatial attention in sensory processing dysfunction, also using both standard ERP and oscillatory hierarchy analyses, and will also evaluate the role of phase reset vs. exogenous activity in ERP generation in patients and controls. Experiment 3 will evaluate spatial attention effects further using ssVEP approaches. Deficits in ERP generation will also be assessed relative to symptomatic and cognitive measures. The fourth experiment will evaluate the role of structural and functional connectivity impairments in etiology of sensory and attentional deficits using MR measures supported by Core B. DTI measures will be used to assess structural connectivity, while resting state fMRI will be used to assess functional connectivity. An underiying hypothesis is that deficits in neurophysiological processes such as non? linear gain and slow oscillatory function that are known to be NMDA receptor-dependent will lead to impaired entrainment of higher-frequency oscillations (e.g. delta, theta, gamma), leading to impaired ERP generation and behavior. Overall, this project will test the hypothesis that deficits in hierarchical processing within regions and structural and functional connectivity between regions lead to deficits in neurocognitive function in schizophrenia.
Schizophrenia is a major mental disorder. Neurocognitive dysfunction is a core component of schizophrenia and a major determinant of poor long-term outcome. This project will evaluate mechanisms underlying deficits in sensory processing and neurocognitive dysfunction in patients with chronic schizophrenia, in collaboration with other projects and core programs in order to develop improved methods for early detection, diagnosis and intervention.
|Ding, Yulong; Martinez, Antigona; Qu, Zhe et al. (2014) Earliest stages of visual cortical processing are not modified by attentional load. Hum Brain Mapp 35:3008-24|
|Brunoni, Andre R; Shiozawa, Pedro; Truong, Dennis et al. (2014) Understanding tDCS effects in schizophrenia: a systematic review of clinical data and an integrated computation modeling analysis. Expert Rev Med Devices 11:383-94|
|Pitts, Michael A; Padwal, Jennifer; Fennelly, Daniel et al. (2014) Gamma band activity and the P3 reflect post-perceptual processes, not visual awareness. Neuroimage 101:337-50|
|Merkel, Christian; Stoppel, Christian M; Hillyard, Steven A et al. (2014) Spatio-temporal patterns of brain activity distinguish strategies of multiple-object tracking. J Cogn Neurosci 26:28-40|
|Revheim, Nadine; Corcoran, Cheryl M; Dias, Elisa et al. (2014) Reading deficits in schizophrenia and individuals at high clinical risk: relationship to sensory function, course of illness, and psychosocial outcome. Am J Psychiatry 171:949-59|
|Schoenfeld, Mircea A; Hopf, Jens-Max; Merkel, Christian et al. (2014) Object-based attention involves the sequential activation of feature-specific cortical modules. Nat Neurosci 17:619-24|
|Gill, Kelly Elizabeth; Evans, Elizabeth; Kayser, Jürgen et al. (2014) Smell identification in individuals at clinical high risk for schizophrenia. Psychiatry Res 220:201-4|
|Feng, Wenfeng; Störmer, Viola S; Martinez, Antigona et al. (2014) Sounds activate visual cortex and improve visual discrimination. J Neurosci 34:9817-24|
|Hoptman, Matthew J; Antonius, Daniel; Mauro, Cristina J et al. (2014) Cortical thinning, functional connectivity, and mood-related impulsivity in schizophrenia: relationship to aggressive attitudes and behavior. Am J Psychiatry 171:939-48|
|Kantrowitz, J T; Hoptman, M J; Leitman, D I et al. (2014) The 5% difference: early sensory processing predicts sarcasm perception in schizophrenia and schizo-affective disorder. Psychol Med 44:25-36|
Showing the most recent 10 out of 47 publications