Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DA008188-03
Application #
2120657
Study Section
Special Emphasis Panel (SRCD (04))
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-02-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Roy, S; Charboneau, R G; Barke, R A (1999) Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model. J Neuroimmunol 95:107-14
Roy, S; Cain, K J; Chapin, R B et al. (1998) Morphine modulates NF kappa B activation in macrophages. Biochem Biophys Res Commun 245:392-6
Roy, S; Cain, K J; Charboneau, R G et al. (1998) Morphine accelerates the progression of sepsis in an experimental sepsis model. Adv Exp Med Biol 437:21-31
Sharp, B M; Roy, S; Bidlack, J M (1998) Evidence for opioid receptors on cells involved in host defense and the immune system. J Neuroimmunol 83:45-56
Carson, L F; Roy, S; Cain, K et al. (1998) The central response to ovarian carcinoma simulates the response to sepsis. J Surg Res 75:97-102
Roy, S; Chapin, R B; Cain, K J et al. (1997) Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes. Cell Immunol 179:1-9
Roy, S; Sedqi, M; Ramakrishnan, S et al. (1996) Differential effects of opioids on the proliferation of a macrophage cell line, Bac 1.2F5. Cell Immunol 169:271-7
Roy, S; Charboneau, R; Cain, K J et al. (1995) The possible role of a central nervous system dopaminergic mechanism in hepatic c-fos protein expression following peritoneal sepsis. Arch Surg 130:1209-15;discussion 1215-6
Chapin, R B; Roy, S; Charboneau, R et al. (1995) Regulation of the transcription factor C/EBP alpha following peritoneal sepsis. J Surg Res 59:460-7
Barke, R A; Roy, S; Chapin, R B et al. (1994) The role of programmed cell death (apoptosis) in thymic involution following sepsis. Arch Surg 129:1256-61;discussion 1261-2