Core B is the Biostafistics and Data Management Core which is responsible for developing and maintaining a relational database of demographic, clinical, genetic, biomarker, and other data gathered by SCOR projects described in the application to examine the impact of early life adversity on the development of stress dysregulation. This core provides database, compufing, and biostatistical direction and analysis support to the research pursued in Projects l-lll. Lastly, Core B will employ and extend existing methodologies for the analysis of the SCOR project data.

Public Health Relevance

Early life adversity is one of the greatest predictors of affective disorder onset in women. Core B will provide database, compufing, and biostatistical direcfion and analysis support to the research pursued in Projects I- III.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH099910-03
Application #
8708982
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
3
Fiscal Year
2014
Total Cost
$135,292
Indirect Cost
$50,734
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Morrison, Kathleen E; Narasimhan, Sneha; Fein, Ethan et al. (2016) Peripubertal Stress With Social Support Promotes Resilience in the Face of Aging. Endocrinology 157:2002-14
Jašarević, Eldin; Morrison, Kathleen E; Bale, Tracy L (2016) Sex differences in the gut microbiome-brain axis across the lifespan. Philos Trans R Soc Lond B Biol Sci 371:20150122
Smith, Ariana L; Hantsoo, Liisa; Malykhina, Anna P et al. (2016) Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder. Int Urogynecol J 27:1383-91
Bronson, Stefanie L; Bale, Tracy L (2016) The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming. Neuropsychopharmacology 41:207-18
Morrison, Kathleen E; Epperson, C Neill; Sammel, Mary D et al. (2016) Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice. Biol Psychiatry :
Jašarević, Eldin; Howerton, Christopher L; Howard, Christopher D et al. (2015) Alterations in the Vaginal Microbiome by Maternal Stress Are Associated With Metabolic Reprogramming of the Offspring Gut and Brain. Endocrinology 156:3265-76
Kim, Deborah R; Bale, Tracy L; Epperson, C Neill (2015) Prenatal programming of mental illness: current understanding of relationship and mechanisms. Curr Psychiatry Rep 17:5
Hantsoo, Liisa; Epperson, C Neill (2015) Premenstrual Dysphoric Disorder: Epidemiology and Treatment. Curr Psychiatry Rep 17:87
Epperson, C Neill; Shanmugan, Sheila; Kim, Deborah R et al. (2015) New onset executive function difficulties at menopause: a possible role for lisdexamfetamine. Psychopharmacology (Berl) 232:3091-100
Nugent, Bridget M; Bale, Tracy L (2015) The omniscient placenta: Metabolic and epigenetic regulation of fetal programming. Front Neuroendocrinol 39:28-37

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