Our SPOTRIAS Program Project includes 3 clinical research subprojects, consisting of novel therapeutic interventions. All of these trials are phase 1 or 2 in their development, and have been conceptualized and designed by our group. One is brand new, and two are the next phase of projects begun during our first SPOTRIAS. The purpose of the Clinical Core is to facilitate this work. The conduct of such clinical trials is complicated requiring careful planning, expert execution, close supervision, detailed monitoring, and complex data analysis. To carry out such research requires excellent clinical facilities, ample patients, collaborative relationships and the skills of experienced investigators, nurse coordinators, and administrative staff. Special problems are inherent in conducting clinical trials that are investigator-initiated since these studies usually do not have the backing of a large funding agency or pharmaceutical company, at least in their early stages, to provide the financial and administrative support to carry out this work. The purpose of this Clinical Core is to improve the capability of orchestrating such early stage research within the Vascular Neurology (VN) Program at the University of Texas Houston Medical School. As a large, well-established Stroke Center with a thriving fellowship training program, we have been conducting investigator-initiated phase 1 and 2 clinical research for many years and have made progress with many challenges inherent in this work. The clinical collaborations, study conduct, and administration of our VN Program that evolved over its first 15 years has been substantially enhanced by the overall administrative structure, plan and central coordination provided over the past 5 years by the SPOTRIAS Clinical Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS044227-10
Application #
8375433
Study Section
Special Emphasis Panel (ZNS1-SRB-G)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
10
Fiscal Year
2012
Total Cost
$687,788
Indirect Cost
$240,282
Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Cai, Chunyan; Rahbar, Mohammad H; Hossain, Md Monir et al. (2017) A placebo-controlled Bayesian dose finding design based on continuous reassessment method with application to stroke research. Contemp Clin Trials Commun 7:11-17
Barreto, Andrew D; Ford, Gary A; Shen, Loren et al. (2017) Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke). Stroke 48:1608-1616
Lyden, Patrick; Hemmen, Thomas; Grotta, James et al. (2016) Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2). Stroke 47:2888-2895
Ifejika, Nneka Lotea; Noser, Elizabeth Anne; Grotta, James C et al. (2016) Swipe out Stroke: Feasibility and efficacy of using a smart-phone based mobile application to improve compliance with weight loss in obese minority stroke patients and their carers. Int J Stroke 11:593-603
McDonald, Mark M; Wetzel, Jeremy; Fraser, Stuart et al. (2016) Thrombelastography does not predict clinical response to rtPA for acute ischemic stroke. J Thromb Thrombolysis 41:505-10
Vahidy, F S; Rahbar, M H; Lal, A P et al. (2015) Patient refusal of thrombolytic therapy for suspected acute ischemic stroke. Int J Stroke 10:882-6
Ifejika, Nneka L; Vahidy, Farhaan; Aramburo-Maldonado, Linda A et al. (2015) Acute Intravenous Tissue Plasminogen Activator Therapy does not Impact Community Discharge after Inpatient Rehabilitation. Int J Neurorehabil 2:
Schlick, Konrad H; Hemmen, Thomas M; Lyden, Patrick D (2015) Seizures and Meperidine: Overstated and Underutilized. Ther Hypothermia Temp Manag 5:223-7
Huang, Richard S P; McDonald, Mark M; Wetzel, Jeremy S et al. (2015) Clot Strength as Measured by Thrombelastography Correlates with Platelet Reactivity in Stroke Patients. Ann Clin Lab Sci 45:301-7
Elliott, Andrea; Wetzel, Jeremy; Roper, Tiffany et al. (2015) Thromboelastography in patients with acute ischemic stroke. Int J Stroke 10:194-201

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